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Sandbox2qc8
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(Difference between revisions)
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| - | The beta strands are arranged into five <scene name='Sandbox2qc8/Pdb_defined_beta_strands/1'>beta sheets</scene>. | + | The beta strands are arranged into five <scene name='Sandbox2qc8/Pdb_defined_beta_strands/1'>beta sheets</scene>. In addition, there are 5 <scene name='Sandbox2qc8/Hairpins/1'>beta hairpins</scene> and 5 <scene name='Sandbox2qc8/Bulges/1'>beta bulges</scene>. <ref>European Bioinformatics Institute, Ligase(amide synthetase), http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=2gls, Accessed December 18, 2008.</ref> |
| - | . | + | |
The active site within the secondary structure can be called a "bifunnel," providing access to ATP and glutamate at opposing ends.<ref>Eisenberg, D., et al., Structure-function relationships of glutamine synthetases, Biochimica et Biophysica Acta 1477 (2000), 122-145.</ref> | The active site within the secondary structure can be called a "bifunnel," providing access to ATP and glutamate at opposing ends.<ref>Eisenberg, D., et al., Structure-function relationships of glutamine synthetases, Biochimica et Biophysica Acta 1477 (2000), 122-145.</ref> | ||
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The only ligand present is a pair of Mn ions (Manganese) that indicates the active site of each subunit of the dodecamer. | The only ligand present is a pair of Mn ions (Manganese) that indicates the active site of each subunit of the dodecamer. | ||
| - | <scene name='Sandbox2qc8/Hairpins/1'>Hairpins</scene>, | ||
| - | <scene name='Sandbox2qc8/Bulges/1'>Bulges</scene>, | ||
<scene name='Sandbox2qc8/Catalytic_sites/1'>Catalytic sites E327, R339, D50</scene><br> | <scene name='Sandbox2qc8/Catalytic_sites/1'>Catalytic sites E327, R339, D50</scene><br> | ||
Revision as of 03:15, 19 December 2008
Glutamine Synthetase: Secondary structures
Glutamine synthetase is composed of 12 . Each subunit is composed of 15 and . Each subunit binds 2 Mn for a total of per Glutamine Synthetase.
Each subunit has an exposed NH2 terminus and buried COOH terminus as part of a . [1]
The beta strands are arranged into five . In addition, there are 5 and 5 . [2]
The active site within the secondary structure can be called a "bifunnel," providing access to ATP and glutamate at opposing ends.[3]
The only ligand present is a pair of Mn ions (Manganese) that indicates the active site of each subunit of the dodecamer.
References
- ↑ Yamashita, M., et al.,Refined Atomic Model of Glutamine Synthetase at 3.5A Resolution, The Journal of Biological Chemistry, 1989, 17681-17690.
- ↑ European Bioinformatics Institute, Ligase(amide synthetase), http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=2gls, Accessed December 18, 2008.
- ↑ Eisenberg, D., et al., Structure-function relationships of glutamine synthetases, Biochimica et Biophysica Acta 1477 (2000), 122-145.
