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3dy7

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'''Unreleased structure'''
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{{Seed}}
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[[Image:3dy7.jpg|left|200px]]
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The entry 3dy7 is ON HOLD until Paper Publication
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{{STRUCTURE_3dy7| PDB=3dy7 | SCENE= }}
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Authors: Ohren, J.F., Pavlovsky, A., Zhang, E.
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===X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP===
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Description: X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 24 11:27:24 2008''
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{{ABSTRACT_PUBMED_19019675}}
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==About this Structure==
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3DY7 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DY7 OCA].
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==Reference==
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<ref group="xtra">PMID:19019675</ref><ref group="xtra">PMID:15543157</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Mitogen-activated protein kinase kinase]]
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[[Category: Ohren, J F.]]
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[[Category: Pavlovsky, A.]]
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[[Category: Zhang, E.]]
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[[Category: Acetylation]]
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[[Category: Atp-binding]]
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[[Category: Atp-bound protein kinase]]
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[[Category: Disease mutation]]
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[[Category: Dual specificity protein kinase]]
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[[Category: Inhibitor-bound protein kinase]]
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[[Category: Non-atp-competitive kinase inhibitor]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphoprotein]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Transferase]]
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[[Category: Tyrosine-protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 17 10:23:11 2009''

Revision as of 07:23, 17 June 2009

Image:3dy7.jpg

Template:STRUCTURE 3dy7

X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP

Template:ABSTRACT PUBMED 19019675

About this Structure

3DY7 is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Tecle H, Shao J, Li Y, Kothe M, Kazmirski S, Penzotti J, Ding YH, Ohren J, Moshinsky D, Coli R, Jhawar N, Bora E, Jacques-O'Hagan S, Wu J. Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK? Bioorg Med Chem Lett. 2009 Jan 1;19(1):226-9. Epub 2008 Oct 31. PMID:19019675 doi:10.1016/j.bmcl.2008.10.108
  • Ohren JF, Chen H, Pavlovsky A, Whitehead C, Zhang E, Kuffa P, Yan C, McConnell P, Spessard C, Banotai C, Mueller WT, Delaney A, Omer C, Sebolt-Leopold J, Dudley DT, Leung IK, Flamme C, Warmus J, Kaufman M, Barrett S, Tecle H, Hasemann CA. Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition. Nat Struct Mol Biol. 2004 Dec;11(12):1192-7. Epub 2004 Nov 14. PMID:15543157 doi:10.1038/nsmb859

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