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3ekk

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Revision as of 06:10, 7 January 2009

Image:3ekk.png

Template:STRUCTURE 3ekk

Contents

Insulin receptor kinase complexed with an inhibitor

Template:ABSTRACT PUBMED 19056263

Disease

Known disease associated with this structure: Diabetes mellitus, insulin-resistant, with acanthosis nigricans OMIM:[147670], Hyperinsulinemic hypoglycemia, familial, 5 OMIM:[147670], Leprechaunism OMIM:[147670], Rabson-Mendenhall syndrome OMIM:[147670]

About this Structure

3EKK is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Discovery of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines: Potent inhibitors of the IGF-1R receptor tyrosine kinase., Chamberlain SD, Wilson JW, Deanda F, Patnaik S, Redman AM, Yang B, Shewchuk L, Sabbatini P, Leesnitzer MA, Groy A, Atkins C, Gerding R, Hassell AM, Lei H, Mook RA Jr, Moorthy G, Rowand JL, Stevens KL, Kumar R, Shotwell JB, Bioorg Med Chem Lett. 2008 Nov 18. PMID:19056263

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