2vwy

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==About this Structure==
==About this Structure==
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2VWY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VWY OCA].
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2VWY is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VWY OCA].
==Reference==
==Reference==
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Inhibitors of the tyrosine kinase EphB4. Part 2: Structure-based discovery and optimisation of 3,5-bis substituted anilinopyrimidines., Bardelle C, Coleman T, Cross D, Davenport S, Kettle JG, Ko EJ, Leach AG, Mortlock A, Read J, Roberts NJ, Robins P, Williams EJ, Bioorg Med Chem Lett. 2008 Sep 27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18851911 18851911]
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<ref group="xtra">PMID:18851911</ref><ref group="xtra">PMID:18434142</ref><references group="xtra"/>
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Inhibitors of the tyrosine kinase EphB4. Part 1: Structure-based design and optimization of a series of 2,4-bis-anilinopyrimidines., Bardelle C, Cross D, Davenport S, Kettle JG, Ko EJ, Leach AG, Mortlock A, Read J, Roberts NJ, Robins P, Williams EJ, Bioorg Med Chem Lett. 2008 May 1;18(9):2776-80. Epub 2008 Apr 10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18434142 18434142]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Receptor protein-tyrosine kinase]]
[[Category: Receptor protein-tyrosine kinase]]
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[[Category: Single protein]]
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[[Category: Barratt, D.]]
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[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
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[[Category: Brassington, C A.]]
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[[Category: Green, I.]]
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[[Category: Kettle, J G.]]
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[[Category: Leach, A G.]]
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[[Category: Mccall, E J.]]
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[[Category: Read, J.]]
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[[Category: Valentine, A L.]]
[[Category: Atp-binding]]
[[Category: Atp-binding]]
[[Category: Glycoprotein]]
[[Category: Glycoprotein]]
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[[Category: Unphosphorylated]]
[[Category: Unphosphorylated]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 24 20:11:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 02:58:19 2009''

Revision as of 00:58, 18 February 2009

Image:2vwy.png

Template:STRUCTURE 2vwy

EPHB4 KINASE DOMAIN INHIBITOR COMPLEX

Template:ABSTRACT PUBMED 18851911

About this Structure

2VWY is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Bardelle C, Coleman T, Cross D, Davenport S, Kettle JG, Ko EJ, Leach AG, Mortlock A, Read J, Roberts NJ, Robins P, Williams EJ. Inhibitors of the tyrosine kinase EphB4. Part 2: structure-based discovery and optimisation of 3,5-bis substituted anilinopyrimidines. Bioorg Med Chem Lett. 2008 Nov 1;18(21):5717-21. Epub 2008 Sep 27. PMID:18851911 doi:10.1016/j.bmcl.2008.09.087
  • Bardelle C, Cross D, Davenport S, Kettle JG, Ko EJ, Leach AG, Mortlock A, Read J, Roberts NJ, Robins P, Williams EJ. Inhibitors of the tyrosine kinase EphB4. Part 1: Structure-based design and optimization of a series of 2,4-bis-anilinopyrimidines. Bioorg Med Chem Lett. 2008 May 1;18(9):2776-80. Epub 2008 Apr 10. PMID:18434142 doi:10.1016/j.bmcl.2008.04.015

Page seeded by OCA on Wed Feb 18 02:58:19 2009

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