3bys

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==About this Structure==
==About this Structure==
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3BYS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BYS OCA].
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3BYS is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BYS OCA].
==Reference==
==Reference==
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Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation., DiMauro EF, Newcomb J, Nunes JJ, Bemis JE, Boucher C, Chai L, Chaffee SC, Deak HL, Epstein LF, Faust T, Gallant P, Gore A, Gu Y, Henkle B, Hsieh F, Huang X, Kim JL, Lee JH, Martin MW, McGowan DC, Metz D, Mohn D, Morgenstern KA, Oliveira-dos-Santos A, Patel VF, Powers D, Rose PE, Schneider S, Tomlinson SA, Tudor YY, Turci SM, Welcher AA, Zhao H, Zhu L, Zhu X, J Med Chem. 2008 Mar 27;51(6):1681-94. Epub 2008 Mar 6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18321037 18321037]
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<ref group="xtra">PMID:18321037</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific protein-tyrosine kinase]]
[[Category: Non-specific protein-tyrosine kinase]]
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[[Category: Single protein]]
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[[Category: Huang, X.]]
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[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
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[[Category: Alternative splicing]]
[[Category: Alternative splicing]]
[[Category: Atp-binding]]
[[Category: Atp-binding]]
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[[Category: Tyrosine-protein kinase]]
[[Category: Tyrosine-protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 31 20:23:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 16:59:31 2009''

Revision as of 14:59, 16 February 2009

Image:3bys.png

Template:STRUCTURE 3bys

Contents

co-crystal structure of Lck and aminopyrimidine amide 10b

Template:ABSTRACT PUBMED 18321037

Disease

Known disease associated with this structure: SCID due to LCK deficiency OMIM:[153390]

About this Structure

3BYS is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • DiMauro EF, Newcomb J, Nunes JJ, Bemis JE, Boucher C, Chai L, Chaffee SC, Deak HL, Epstein LF, Faust T, Gallant P, Gore A, Gu Y, Henkle B, Hsieh F, Huang X, Kim JL, Lee JH, Martin MW, McGowan DC, Metz D, Mohn D, Morgenstern KA, Oliveira-dos-Santos A, Patel VF, Powers D, Rose PE, Schneider S, Tomlinson SA, Tudor YY, Turci SM, Welcher AA, Zhao H, Zhu L, Zhu X. Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation. J Med Chem. 2008 Mar 27;51(6):1681-94. Epub 2008 Mar 6. PMID:18321037 doi:10.1021/jm7010996

Page seeded by OCA on Mon Feb 16 16:59:31 2009

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