3f8g

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'''Unreleased structure'''
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{{Seed}}
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[[Image:3f8g.jpg|left|200px]]
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The entry 3f8g is ON HOLD until Paper Publication
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{{STRUCTURE_3f8g| PDB=3f8g | SCENE= }}
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Authors: Merlino, A., Avella, G., Mazzarella, L., Sica, F.
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===The X-ray structure of a dimeric variant of human pancreatic ribonuclease with high cytotoxic and antitumor activities===
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Description: The X-ray structure of a dimeric variant of human pancreatic ribonuclease with high cytotoxic and antitumor activities
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 7 09:34:21 2009''
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{{ABSTRACT_PUBMED_19177350}}
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==About this Structure==
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3F8G is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F8G OCA].
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==Reference==
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<ref group="xtra">PMID:19177350</ref><ref group="xtra">PMID:15192098</ref><ref group="xtra">PMID:18164315</ref><ref group="xtra">PMID:10393896</ref><ref group="xtra">PMID:11485573</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Pancreatic ribonuclease]]
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[[Category: Avella, G.]]
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[[Category: Mazzarella, L.]]
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[[Category: Merlino, A.]]
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[[Category: Sica, F.]]
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[[Category: 3d domain swapping]]
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[[Category: Antitumor agent]]
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[[Category: Dimer]]
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[[Category: Endonuclease]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Nuclease]]
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[[Category: Ribonuclease]]
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[[Category: Secreted]]
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[[Category: Unswapped dimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 11 12:43:09 2009''

Revision as of 10:43, 11 February 2009

Image:3f8g.jpg

Template:STRUCTURE 3f8g

The X-ray structure of a dimeric variant of human pancreatic ribonuclease with high cytotoxic and antitumor activities

Template:ABSTRACT PUBMED 19177350

About this Structure

3F8G is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Merlino A, Avella G, Di Gaetano S, Arciello A, Piccoli R, Mazzarella L, Sica F. Structural features for the mechanism of antitumor action of a dimeric human pancreatic ribonuclease variant. Protein Sci. 2009 Jan;18(1):50-7. PMID:19177350 doi:10.1002/pro.6
  • Sica F, Di Fiore A, Merlino A, Mazzarella L. Structure and stability of the non-covalent swapped dimer of bovine seminal ribonuclease: an enzyme tailored to evade ribonuclease protein inhibitor. J Biol Chem. 2004 Aug 27;279(35):36753-60. Epub 2004 Jun 9. PMID:15192098 doi:http://dx.doi.org/10.1074/jbc.M405655200
  • Merlino A, Ercole C, Picone D, Pizzo E, Mazzarella L, Sica F. The buried diversity of bovine seminal ribonuclease: shape and cytotoxicity of the swapped non-covalent form of the enzyme. J Mol Biol. 2008 Feb 15;376(2):427-37. Epub 2007 Nov 12. PMID:18164315 doi:http://dx.doi.org/10.1016/j.jmb.2007.11.008
  • Piccoli R, Di Gaetano S, De Lorenzo C, Grauso M, Monaco C, Spalletti-Cernia D, Laccetti P, Cinatl J, Matousek J, D'Alessio G. A dimeric mutant of human pancreatic ribonuclease with selective cytotoxicity toward malignant cells. Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):7768-73. PMID:10393896
  • Di Gaetano S, D'alessio G, Piccoli R. Second generation antitumour human RNase: significance of its structural and functional features for the mechanism of antitumour action. Biochem J. 2001 Aug 15;358(Pt 1):241-7. PMID:11485573

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