3ekn

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{{ABSTRACT_PUBMED_19071018}}
{{ABSTRACT_PUBMED_19071018}}
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==Disease==
 
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Known disease associated with this structure: Diabetes mellitus, insulin-resistant, with acanthosis nigricans OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147670 147670]], Hyperinsulinemic hypoglycemia, familial, 5 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147670 147670]], Leprechaunism OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147670 147670]], Rabson-Mendenhall syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147670 147670]]
 
==About this Structure==
==About this Structure==
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3EKN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EKN OCA].
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3EKN is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EKN OCA].
==Reference==
==Reference==
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Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity., Chamberlain SD, Redman AM, Wilson JW, Deanda F, Shotwell JB, Gerding R, Lei H, Yang B, Stevens KL, Hassell AM, Shewchuk LM, Leesnitzer MA, Smith JL, Sabbatini P, Atkins C, Groy A, Rowand JL, Kumar R, Mook RA Jr, Moorthy G, Patnaik S, Bioorg Med Chem Lett. 2009 Jan 15;19(2):360-4. Epub 2008 Nov 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/19071018 19071018]
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<ref group="xtra">PMID:19071018</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Receptor protein-tyrosine kinase]]
[[Category: Receptor protein-tyrosine kinase]]
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[[Category: Single protein]]
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[[Category: Atkins, C.]]
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[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
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[[Category: Chamberlain, S.]]
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[[Category: Deanda, F.]]
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[[Category: Dumble, M.]]
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[[Category: Gerding, R.]]
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[[Category: Groy, A.]]
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[[Category: Korenchuk, S.]]
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[[Category: Kumar, R.]]
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[[Category: Lei, H.]]
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[[Category: Mook, R.]]
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[[Category: Moorthy, G.]]
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[[Category: Redman, A.]]
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[[Category: Rowland, J.]]
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[[Category: Shewchuk, L.]]
[[Category: Alternative splicing]]
[[Category: Alternative splicing]]
[[Category: Atp-binding]]
[[Category: Atp-binding]]
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[[Category: Tyrosine-protein kinase]]
[[Category: Tyrosine-protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 7 20:12:56 2009''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 11:42:08 2010''

Revision as of 08:33, 22 September 2010

Image:3ekn.png

Template:STRUCTURE 3ekn

Insulin receptor kinase complexed with an inhibitor

Template:ABSTRACT PUBMED 19071018

About this Structure

3EKN is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Chamberlain SD, Redman AM, Wilson JW, Deanda F, Shotwell JB, Gerding R, Lei H, Yang B, Stevens KL, Hassell AM, Shewchuk LM, Leesnitzer MA, Smith JL, Sabbatini P, Atkins C, Groy A, Rowand JL, Kumar R, Mook RA Jr, Moorthy G, Patnaik S. Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity. Bioorg Med Chem Lett. 2009 Jan 15;19(2):360-4. Epub 2008 Nov 24. PMID:19071018 doi:S0960-894X(08)01461-3

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