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3d0a
From Proteopedia
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{{STRUCTURE_3d0a| PDB=3d0a | SCENE= }} | {{STRUCTURE_3d0a| PDB=3d0a | SCENE= }} | ||
===Human p53 core domain with hot spot mutation R249S and second site suppressor mutation H168R in sequence-specific complex with DNA=== | ===Human p53 core domain with hot spot mutation R249S and second site suppressor mutation H168R in sequence-specific complex with DNA=== | ||
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{{ABSTRACT_PUBMED_18996393}} | {{ABSTRACT_PUBMED_18996393}} | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: Adrenal cortical carcinoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Breast cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Colorectal cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Hepatocellular carcinoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Histiocytoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Li-Fraumeni syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Multiple malignancy syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Nasopharyngeal carcinoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Osteosarcoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Pancreatic cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Thyroid carcinoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3d0a]] is a 8 chain structure of [[P53]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D0A OCA]. | |
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| + | ==See Also== | ||
| + | *[[P53|P53]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:018996393</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Rozenberg, H.]] | [[Category: Rozenberg, H.]] | ||
[[Category: Shakked, Z.]] | [[Category: Shakked, Z.]] | ||
[[Category: Suad, O.]] | [[Category: Suad, O.]] | ||
| - | [[Category: Acetylation]] | ||
[[Category: Activator]] | [[Category: Activator]] | ||
| - | [[Category: Alternative splicing]] | ||
[[Category: Anti-oncogene]] | [[Category: Anti-oncogene]] | ||
[[Category: Apoptosis]] | [[Category: Apoptosis]] | ||
[[Category: Cell cycle]] | [[Category: Cell cycle]] | ||
[[Category: Covalent protein-rna linkage]] | [[Category: Covalent protein-rna linkage]] | ||
| - | [[Category: Cytoplasm]] | ||
[[Category: Disease mutation]] | [[Category: Disease mutation]] | ||
[[Category: Dna target]] | [[Category: Dna target]] | ||
| Line 53: | Line 38: | ||
[[Category: P53]] | [[Category: P53]] | ||
[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
| - | [[Category: Polymorphism]] | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||
[[Category: Transcription regulation]] | [[Category: Transcription regulation]] | ||
| - | [[Category: Transcription | + | [[Category: Transcription-dna complex]] |
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Revision as of 02:25, 27 July 2012
Contents |
Human p53 core domain with hot spot mutation R249S and second site suppressor mutation H168R in sequence-specific complex with DNA
Template:ABSTRACT PUBMED 18996393
About this Structure
3d0a is a 8 chain structure of P53 with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Suad O, Rozenberg H, Brosh R, Diskin-Posner Y, Kessler N, Shimon LJ, Frolow F, Liran A, Rotter V, Shakked Z. Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations. J Mol Biol. 2009 Jan 9;385(1):249-65. Epub 2008 Oct 30. PMID:18996393 doi:10.1016/j.jmb.2008.10.063
Categories: Homo sapiens | Rozenberg, H. | Shakked, Z. | Suad, O. | Activator | Anti-oncogene | Apoptosis | Cell cycle | Covalent protein-rna linkage | Disease mutation | Dna target | Dna-binding | Endoplasmic reticulum | Glycoprotein | Host-virus interaction | Li-fraumeni syndrome | Loop-sheet-helix motif | Metal-binding | Methylation | Mutant protein | Nucleus | P53 | Phosphoprotein | Transcription | Transcription regulation | Transcription-dna complex
