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2w1f

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Revision as of 18:14, 11 November 2009

Image:2w1f.png

Template:STRUCTURE 2w1f

STRUCTURE DETERMINATION OF AURORA KINASE IN COMPLEX WITH INHIBITOR

Template:ABSTRACT PUBMED 19143567

About this Structure

2W1F is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Howard S, Berdini V, Boulstridge JA, Carr MG, Cross DM, Curry J, Devine LA, Early TR, Fazal L, Gill AL, Heathcote M, Maman S, Matthews JE, McMenamin RL, Navarro EF, O'Brien MA, O'Reilly M, Rees DC, Reule M, Tisi D, Williams G, Vinkovic M, Wyatt PG. Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity. J Med Chem. 2009 Jan 22;52(2):379-88. PMID:19143567 doi:10.1021/jm800984v

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