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Template:STRUCTURE 1x70

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{{Structure
{{Structure
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|PDB= {{{PDB}}}|SCENE={{{SCENE|}}}|SIZE={{{SIZE|350}}}|CAPTION={{{CAPTION|[[1x70]], resolution 2.10&Aring; (<scene name='initialview01'>default scene</scene>)}}}
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|PDB= {{{PDB}}}|SCENE={{{SCENE|}}}|SIZE={{{SIZE|350}}}|CAPTION={{{CAPTION|[[1x70]], [[Resolution|resolution]] 2.10&Aring; (<scene name='initialview01'>default scene</scene>)}}}
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|LIGAND= <scene name='pdbligand=715:(2R)-4-OXO-4-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE'>715</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:SUGAR+(N-ACETYL-D-GLUCOSAMINE)'>NAG</scene>
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|SITE= <scene name='pdbsite=AC1:Binding+Site+For+Residue+Nag+A+1085'>AC1</scene>, <scene name='pdbsite=AC2:Binding+Site+For+Residue+Ndg+A+1086'>AC2</scene>, <scene name='pdbsite=AC3:Binding+Site+For+Residue+Nag+A+1092'>AC3</scene>, <scene name='pdbsite=AC4:Binding+Site+For+Residue+Ndg+A+1150'>AC4</scene>, <scene name='pdbsite=AC5:Binding+Site+For+Residue+Nag+A+1151'>AC5</scene>, <scene name='pdbsite=AC6:Binding+Site+For+Residue+Nag+A+1219'>AC6</scene>, <scene name='pdbsite=AC7:Binding+Site+For+Residue+Nag+A+1220'>AC7</scene>, <scene name='pdbsite=AC8:Binding+Site+For+Residue+Nag+A+1229'>AC8</scene>, <scene name='pdbsite=AC9:Binding+Site+For+Residue+Ndg+A+1230'>AC9</scene>, <scene name='pdbsite=BC1:Binding+Site+For+Residue+Nag+A+1281'>BC1</scene>, <scene name='pdbsite=BC2:Binding+Site+For+Residue+Nag+A+1321'>BC2</scene>, <scene name='pdbsite=BC3:Binding+Site+For+Residue+Nag+A+1322'>BC3</scene>, <scene name='pdbsite=BC4:Binding+Site+For+Residue+Nag+A+1520'>BC4</scene>, <scene name='pdbsite=BC5:Binding+Site+For+Residue+Nag+B+2085'>BC5</scene>, <scene name='pdbsite=BC6:Binding+Site+For+Residue+Nag+B+2086'>BC6</scene>, <scene name='pdbsite=BC7:Binding+Site+For+Residue+Nag+B+2092'>BC7</scene>, <scene name='pdbsite=BC8:Binding+Site+For+Residue+Nag+B+2150'>BC8</scene>, <scene name='pdbsite=BC9:Binding+Site+For+Residue+Nag+B+2219'>BC9</scene>, <scene name='pdbsite=CC1:Binding+Site+For+Residue+Nag+B+2220'>CC1</scene>, <scene name='pdbsite=CC2:Binding+Site+For+Residue+Nag+B+2229'>CC2</scene>, <scene name='pdbsite=CC3:Binding+Site+For+Residue+Nag+B+2230'>CC3</scene>, <scene name='pdbsite=CC4:Binding+Site+For+Residue+Nag+B+2281'>CC4</scene>, <scene name='pdbsite=CC5:Binding+Site+For+Residue+Nag+B+2282'>CC5</scene>, <scene name='pdbsite=CC6:Binding+Site+For+Residue+Nag+B+2321'>CC6</scene>, <scene name='pdbsite=CC7:Binding+Site+For+Residue+Na+A+1200'>CC7</scene>, <scene name='pdbsite=CC8:Binding+Site+For+Residue+715+A+801'>CC8</scene> and <scene name='pdbsite=CC9:Binding+Site+For+Residue+715+B+801'>CC9</scene>
 +
|LIGAND= <scene name='pdbligand=715:(2R)-4-OXO-4-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE'>715</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:SUGAR+(N-ACETYL-D-GLUCOSAMINE)'>NAG</scene>, <scene name='pdbligand=NDG:'>NDG</scene>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span>
|GENE= DPP4, ADCP2, CD26 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
|GENE= DPP4, ADCP2, CD26 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam00326 Peptidase_S9], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam00930 DPPIV_N]</span>
 
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|NONSTDRES=<scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>
 
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x70 OCA], [http://www.ebi.ac.uk/pdbsum/1x70 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1x70 RCSB]</span>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x70 OCA], [http://www.ebi.ac.uk/pdbsum/1x70 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1x70 RCSB]</span>
|FUNCTION={{GO|id=GO:0008233 | text = peptidase activity}}{{GO|id=GO:0004274 | text = dipeptidyl-peptidase IV activity}}{{GO|id=GO:0004287 | text = prolyl oligopeptidase activity}}{{GO|id=GO:0016787 | text = hydrolase activity}}{{GO|id=GO:0004177 | text = aminopeptidase activity}}{{GO|id=GO:0008236 | text = serine-type peptidase activity}}{{GO|id=GO:0004252 | text = serine-type endopeptidase activity}}
|FUNCTION={{GO|id=GO:0008233 | text = peptidase activity}}{{GO|id=GO:0004274 | text = dipeptidyl-peptidase IV activity}}{{GO|id=GO:0004287 | text = prolyl oligopeptidase activity}}{{GO|id=GO:0016787 | text = hydrolase activity}}{{GO|id=GO:0004177 | text = aminopeptidase activity}}{{GO|id=GO:0008236 | text = serine-type peptidase activity}}{{GO|id=GO:0004252 | text = serine-type endopeptidase activity}}
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|COMPONENT={{GO|id=GO:0016020 | text = membrane}}{{GO|id=GO:0016021 | text = integral to membrane}}
|COMPONENT={{GO|id=GO:0016020 | text = membrane}}{{GO|id=GO:0016021 | text = integral to membrane}}
|SARESOURCES=<span class='plainlinks'>CATH : [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1x70A01 1X70A01], [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1x70A02 1X70A02], [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1x70B01 1X70B01], [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1x70B02 1X70B02]<br>InterPro : [http://www.ebi.ac.uk/interpro/ISearch?query=IPR002471 Ipr002471], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR001375 Ipr001375], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR002469 Ipr002469]<br>Pfam : [http://pfam.sanger.ac.uk/family?acc=PF00326 PF00326], [http://pfam.sanger.ac.uk/family?acc=PF00930 PF00930]<br>UniProt : [http://ca.expasy.org/cgi-bin/niceprot.pl?P27487 P27487]</span>
|SARESOURCES=<span class='plainlinks'>CATH : [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1x70A01 1X70A01], [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1x70A02 1X70A02], [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1x70B01 1X70B01], [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1x70B02 1X70B02]<br>InterPro : [http://www.ebi.ac.uk/interpro/ISearch?query=IPR002471 Ipr002471], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR001375 Ipr001375], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR002469 Ipr002469]<br>Pfam : [http://pfam.sanger.ac.uk/family?acc=PF00326 PF00326], [http://pfam.sanger.ac.uk/family?acc=PF00930 PF00930]<br>UniProt : [http://ca.expasy.org/cgi-bin/niceprot.pl?P27487 P27487]</span>
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|FARESOURCES=<span class='plainlinks'>GeneCard : [http://www.genecards.org/cgi-bin/carddisp.pl?id=DPP4 DPP4]</span>
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|uPDB=1X70|CONSURF={{!}}-
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|CONSURF={{!}}-
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{{!}} colspan="2" style="background-color:#bac9f7;color:#040d44;vertical-align:top;text-align:left;" {{!}} [[Image:Consurf_key_small.gif|center]]
{{!}} colspan="2" style="background-color:#bac9f7;color:#040d44;vertical-align:top;text-align:left;" {{!}} [[Image:Consurf_key_small.gif|center]]
{{!}}-{{!}} style="background-color:#bac9f7;color:#040d44;vertical-align:top;text-align:left;"
{{!}}-{{!}} style="background-color:#bac9f7;color:#040d44;vertical-align:top;text-align:left;"

Revision as of 12:25, 28 December 2010

Drag the structure with the mouse to rotate
1x70, resolution 2.10Å ()
Sites: , , , , , , , , , , , , , , , , , , , , , , , , , and
Ligands: , , ,
Gene: DPP4, ADCP2, CD26 (Homo sapiens)
Activity: Dipeptidyl-peptidase IV, with EC number 3.4.14.5
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml


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