1qz2
From Proteopedia
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{{STRUCTURE_1qz2| PDB=1qz2 | SCENE= }} | {{STRUCTURE_1qz2| PDB=1qz2 | SCENE= }} | ||
===Crystal Structure of FKBP52 C-terminal Domain complex with the C-terminal peptide MEEVD of Hsp90=== | ===Crystal Structure of FKBP52 C-terminal Domain complex with the C-terminal peptide MEEVD of Hsp90=== | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | [[1qz2]] is a 5 chain structure of [[FK506 binding protein]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZ2 OCA]. | |
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| + | ==See Also== | ||
| + | *[[FK506 binding protein|FK506 binding protein]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:015159550</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Peptidylprolyl isomerase]] | [[Category: Peptidylprolyl isomerase]] | ||
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[[Category: Heat shock]] | [[Category: Heat shock]] | ||
[[Category: Isomerase]] | [[Category: Isomerase]] | ||
| + | [[Category: Isomerase-chaperone complex]] | ||
[[Category: Rotamase]] | [[Category: Rotamase]] | ||
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Revision as of 11:00, 25 July 2012
Contents |
Crystal Structure of FKBP52 C-terminal Domain complex with the C-terminal peptide MEEVD of Hsp90
FK506-binding protein 52 (FKBP52), which binds FK506 and possesses peptidylprolyl isomerase activity, is an important immunophilin involved in the heterocomplex of steroid receptors with heat-shock protein 90. Here we report the crystal structures of two overlapped fragments [N(1-260) and C(145-459)] of FKBP52 and the complex with a C-terminal pentapeptide from heat-shock protein 90. Based on the structures of these two overlapped fragments, the complete putative structure of FKBP52 can be defined. The structure of FKBP52 is composed of two consecutive FKBP domains, a tetratricopeptide repeat domain and a short helical domain beyond the final tetratricopeptide repeat motif. Key structural differences between FKBP52 and FKBP51, including the relative orientations of the four domains and some important residue substitutions, could account for the differential functions of FKBPs.
3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex., Wu B, Li P, Liu Y, Lou Z, Ding Y, Shu C, Ye S, Bartlam M, Shen B, Rao Z, Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8348-53. Epub 2004 May 24. PMID:15159550
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1qz2 is a 5 chain structure of FK506 binding protein with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Wu B, Li P, Liu Y, Lou Z, Ding Y, Shu C, Ye S, Bartlam M, Shen B, Rao Z. 3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex. Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8348-53. Epub 2004 May 24. PMID:15159550 doi:10.1073/pnas.0305969101
Categories: Homo sapiens | Peptidylprolyl isomerase | Ding, Y. | Li, P. | Liu, Y. | Lou, Z. | Rao, Z. | Shen, B. | Shu, C. | Wu, B. | Chaperone | Heat shock | Isomerase | Isomerase-chaperone complex | Rotamase
