1xod
From Proteopedia
(New page: 200px<br /><applet load="1xod" size="450" color="white" frame="true" align="right" spinBox="true" caption="1xod, resolution 1.15Å" /> '''Crystal structure of...) |
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| - | [[Image:1xod.gif|left|200px]]<br /><applet load="1xod" size=" | + | [[Image:1xod.gif|left|200px]]<br /><applet load="1xod" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1xod, resolution 1.15Å" /> | caption="1xod, resolution 1.15Å" /> | ||
'''Crystal structure of X. tropicalis Spred1 EVH-1 domain'''<br /> | '''Crystal structure of X. tropicalis Spred1 EVH-1 domain'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The recently described Spred protein family has been implicated in the | + | The recently described Spred protein family has been implicated in the modulation of receptor tyrosine kinase signalling. We report the crystal structure of the Enabled/vasodilator-stimulated phosphoprotein homology-1 (EVH1) domain from Xenopus tropicalis Spred1, solved to 1.15 A resolution. This structure confirms that the Spred EVH1 adopts the pleckstrin-homology fold, with a similar secondary structure to Enabled. A translation of one of the peptide-binding groove beta-strands narrows this groove, whilst one end of the groove shows structural flexibility. We propose that Spred1 will bind peptides that are less proline-rich than other EVH1 domains, with conformational changes indicating an induced fit. |
==About this Structure== | ==About this Structure== | ||
| - | 1XOD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Xenopus_tropicalis Xenopus tropicalis] with GOL as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1XOD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Xenopus_tropicalis Xenopus tropicalis] with <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XOD OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Xenopus tropicalis]] | [[Category: Xenopus tropicalis]] | ||
[[Category: Amaya, E.]] | [[Category: Amaya, E.]] | ||
| - | [[Category: Blundell, T | + | [[Category: Blundell, T L.]] |
| - | [[Category: Harmer, N | + | [[Category: Harmer, N J.]] |
| - | [[Category: Sivak, J | + | [[Category: Sivak, J M.]] |
[[Category: GOL]] | [[Category: GOL]] | ||
[[Category: evh1]] | [[Category: evh1]] | ||
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[[Category: sprouty]] | [[Category: sprouty]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:56:56 2008'' |
Revision as of 13:56, 21 February 2008
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Crystal structure of X. tropicalis Spred1 EVH-1 domain
Overview
The recently described Spred protein family has been implicated in the modulation of receptor tyrosine kinase signalling. We report the crystal structure of the Enabled/vasodilator-stimulated phosphoprotein homology-1 (EVH1) domain from Xenopus tropicalis Spred1, solved to 1.15 A resolution. This structure confirms that the Spred EVH1 adopts the pleckstrin-homology fold, with a similar secondary structure to Enabled. A translation of one of the peptide-binding groove beta-strands narrows this groove, whilst one end of the groove shows structural flexibility. We propose that Spred1 will bind peptides that are less proline-rich than other EVH1 domains, with conformational changes indicating an induced fit.
About this Structure
1XOD is a Single protein structure of sequence from Xenopus tropicalis with as ligand. Full crystallographic information is available from OCA.
Reference
1.15 A crystal structure of the X. tropicalis Spred1 EVH1 domain suggests a fourth distinct peptide-binding mechanism within the EVH1 family., Harmer NJ, Sivak JM, Amaya E, Blundell TL, FEBS Lett. 2005 Feb 14;579(5):1161-6. PMID:15710406
Page seeded by OCA on Thu Feb 21 15:56:56 2008
Categories: Single protein | Xenopus tropicalis | Amaya, E. | Blundell, T L. | Harmer, N J. | Sivak, J M. | GOL | Evh1 | Peptide-binding | Spred | Sprouty
