2d5g
From Proteopedia
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{{STRUCTURE_2d5g| PDB=2d5g | SCENE= }} | {{STRUCTURE_2d5g| PDB=2d5g | SCENE= }} | ||
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===Structure of ubiquitin fold protein R767E mutant=== | ===Structure of ubiquitin fold protein R767E mutant=== | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/AXN1_RAT AXN1_RAT]] Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates beta-catenin to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. Also facilitates the phosphorylation of APC by GSK3B. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (By similarity). | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[2d5g]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D5G OCA]. | |
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| + | ==See Also== | ||
| + | *[[Axin|Axin]] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Higuchi, Y.]] | [[Category: Higuchi, Y.]] | ||
[[Category: Shibata, N.]] | [[Category: Shibata, N.]] | ||
| + | [[Category: Signaling protein]] | ||
[[Category: Ubiquitin fold]] | [[Category: Ubiquitin fold]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 13:06:36 2009'' | ||
Revision as of 08:18, 23 April 2014
Contents |
Structure of ubiquitin fold protein R767E mutant
Function
[AXN1_RAT] Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates beta-catenin to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. Also facilitates the phosphorylation of APC by GSK3B. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (By similarity).
About this Structure
2d5g is a 6 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
