1y12
From Proteopedia
(New page: 200px<br /><applet load="1y12" size="450" color="white" frame="true" align="right" spinBox="true" caption="1y12, resolution 1.95Å" /> '''Structure of a hemol...) |
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| - | [[Image:1y12.gif|left|200px]]<br /><applet load="1y12" size=" | + | [[Image:1y12.gif|left|200px]]<br /><applet load="1y12" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1y12, resolution 1.95Å" /> | caption="1y12, resolution 1.95Å" /> | ||
'''Structure of a hemolysin-coregulated protein from Pseudomonas aeruginosa'''<br /> | '''Structure of a hemolysin-coregulated protein from Pseudomonas aeruginosa'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Bacterial pathogens frequently use protein secretion to mediate | + | Bacterial pathogens frequently use protein secretion to mediate interactions with their hosts. Here we found that a virulence locus (HSI-I) of Pseudomonas aeruginosa encodes a protein secretion apparatus. The apparatus assembled in discrete subcellular locations and exported Hcp1, a hexameric protein that forms rings with a 40 angstrom internal diameter. Regulatory patterns of HSI-I suggested that the apparatus functions during chronic infections. We detected Hcp1 in pulmonary secretions of cystic fibrosis (CF) patients and Hcp1-specific antibodies in their sera. Thus, HSI-I likely contributes to the pathogenesis of P. aeruginosa in CF patients. HSI-I-related loci are widely distributed among bacterial pathogens and may play a general role in mediating host interactions. |
==About this Structure== | ==About this Structure== | ||
| - | 1Y12 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http:// | + | 1Y12 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y12 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Pseudomonas aeruginosa]] | [[Category: Pseudomonas aeruginosa]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Cuff, M | + | [[Category: Cuff, M E.]] |
[[Category: Joachimiak, A.]] | [[Category: Joachimiak, A.]] | ||
| - | [[Category: MCSG, Midwest | + | [[Category: MCSG, Midwest Center for Structural Genomics.]] |
[[Category: Zhou, M.]] | [[Category: Zhou, M.]] | ||
[[Category: hemolysin-corregulation]] | [[Category: hemolysin-corregulation]] | ||
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[[Category: structural genomics]] | [[Category: structural genomics]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:00:43 2008'' |
Revision as of 14:00, 21 February 2008
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Structure of a hemolysin-coregulated protein from Pseudomonas aeruginosa
Overview
Bacterial pathogens frequently use protein secretion to mediate interactions with their hosts. Here we found that a virulence locus (HSI-I) of Pseudomonas aeruginosa encodes a protein secretion apparatus. The apparatus assembled in discrete subcellular locations and exported Hcp1, a hexameric protein that forms rings with a 40 angstrom internal diameter. Regulatory patterns of HSI-I suggested that the apparatus functions during chronic infections. We detected Hcp1 in pulmonary secretions of cystic fibrosis (CF) patients and Hcp1-specific antibodies in their sera. Thus, HSI-I likely contributes to the pathogenesis of P. aeruginosa in CF patients. HSI-I-related loci are widely distributed among bacterial pathogens and may play a general role in mediating host interactions.
About this Structure
1Y12 is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.
Reference
A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus., Mougous JD, Cuff ME, Raunser S, Shen A, Zhou M, Gifford CA, Goodman AL, Joachimiak G, Ordonez CL, Lory S, Walz T, Joachimiak A, Mekalanos JJ, Science. 2006 Jun 9;312(5779):1526-30. PMID:16763151
Page seeded by OCA on Thu Feb 21 16:00:43 2008
