1rr8
From Proteopedia
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{{STRUCTURE_1rr8| PDB=1rr8 | SCENE= }} | {{STRUCTURE_1rr8| PDB=1rr8 | SCENE= }} | ||
===Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I=== | ===Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I=== | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: DNA topoisomerase I, camptothecin-resistant OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=126420 126420]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[1rr8]] is a 3 chain structure of [[Topoisomerase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RR8 OCA]. | |
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| + | ==See Also== | ||
| + | *[[Topoisomerase|Topoisomerase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:015165849</ref><references group="xtra"/> |
[[Category: DNA topoisomerase]] | [[Category: DNA topoisomerase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
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[[Category: Camptothecin]] | [[Category: Camptothecin]] | ||
[[Category: Human topoisomerase i]] | [[Category: Human topoisomerase i]] | ||
| + | [[Category: Isomerase-dna complex]] | ||
[[Category: Nucleic acid]] | [[Category: Nucleic acid]] | ||
[[Category: Protein-dna complex]] | [[Category: Protein-dna complex]] | ||
[[Category: Topotecan]] | [[Category: Topotecan]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:51:35 2009'' | ||
Revision as of 15:18, 25 July 2012
Contents |
Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I
Template:ABSTRACT PUBMED 15165849
About this Structure
1rr8 is a 3 chain structure of Topoisomerase with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Chrencik JE, Staker BL, Burgin AB, Pourquier P, Pommier Y, Stewart L, Redinbo MR. Mechanisms of camptothecin resistance by human topoisomerase I mutations. J Mol Biol. 2004 Jun 11;339(4):773-84. PMID:15165849 doi:http://dx.doi.org/10.1016/j.jmb.2004.03.077
