2vts

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===IDENTIFICATION OF N-(4-PIPERIDINYL)-4-(2,6-DICHLOROBENZOYLAMINO)-1H-PYRAZOLE-3-CARBOXAMIDE (AT7519), A NOVEL CYCLIN DEPENDENT KINASE INHIBITOR USING FRAGMENT-BASED X-RAY CRYSTALLOGRAPHY AND STRUCTURE BASED DRUG DESIGN.===
===IDENTIFICATION OF N-(4-PIPERIDINYL)-4-(2,6-DICHLOROBENZOYLAMINO)-1H-PYRAZOLE-3-CARBOXAMIDE (AT7519), A NOVEL CYCLIN DEPENDENT KINASE INHIBITOR USING FRAGMENT-BASED X-RAY CRYSTALLOGRAPHY AND STRUCTURE BASED DRUG DESIGN.===
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{{ABSTRACT_PUBMED_18656911}}
==About this Structure==
==About this Structure==
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2VTS is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VTS OCA].
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2VTS is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VTS OCA].
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==Reference==
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<ref group="xtra">PMID:18656911</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Berdini, V.]]
[[Category: Berdini, V.]]
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[[Category: Saxty, G.]]
[[Category: Saxty, G.]]
[[Category: Seavers, L C.A.]]
[[Category: Seavers, L C.A.]]
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[[Category: Smith, D M.]]
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[[Category: Smith, D.]]
[[Category: Squires, M S.]]
[[Category: Squires, M S.]]
[[Category: Trewartha, G.]]
[[Category: Trewartha, G.]]
[[Category: Walker, M T.]]
[[Category: Walker, M T.]]
[[Category: Woodhead, A J.]]
[[Category: Woodhead, A J.]]
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[[Category: Woolford, A J.A.]]
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[[Category: Woolford, A J.]]
[[Category: Wyatt, P G.]]
[[Category: Wyatt, P G.]]
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[[Category: Atp-binding]]
 
[[Category: Cell cycle]]
[[Category: Cell cycle]]
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[[Category: Cell division]]
 
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[[Category: Fragment screening]]
 
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[[Category: Kinase]]
 
[[Category: Mitosis]]
[[Category: Mitosis]]
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[[Category: Nucleotide-binding]]
 
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[[Category: Phosphoprotein]]
 
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[[Category: Phosphorylation]]
 
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[[Category: Polymorphism]]
 
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[[Category: Protein kinase]]
 
[[Category: Serine/threonine protein kinase]]
[[Category: Serine/threonine protein kinase]]
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[[Category: Serine/threonine-protein kinase]]
 
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[[Category: Structure based drug design]]
 
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 15:09:52 2009''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 3 11:18:16 2010''

Revision as of 08:07, 3 November 2010

Image:2vts.png

Template:STRUCTURE 2vts

IDENTIFICATION OF N-(4-PIPERIDINYL)-4-(2,6-DICHLOROBENZOYLAMINO)-1H-PYRAZOLE-3-CARBOXAMIDE (AT7519), A NOVEL CYCLIN DEPENDENT KINASE INHIBITOR USING FRAGMENT-BASED X-RAY CRYSTALLOGRAPHY AND STRUCTURE BASED DRUG DESIGN.

Template:ABSTRACT PUBMED 18656911

About this Structure

2VTS is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Wyatt PG, Woodhead AJ, Berdini V, Boulstridge JA, Carr MG, Cross DM, Davis DJ, Devine LA, Early TR, Feltell RE, Lewis EJ, McMenamin RL, Navarro EF, O'Brien MA, O'Reilly M, Reule M, Saxty G, Seavers LC, Smith DM, Squires MS, Trewartha G, Walker MT, Woolford AJ. Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design. J Med Chem. 2008 Aug 28;51(16):4986-99. Epub 2008 Jul 26. PMID:18656911 doi:10.1021/jm800382h

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