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1y54
From Proteopedia
(New page: 200px<br /><applet load="1y54" size="450" color="white" frame="true" align="right" spinBox="true" caption="1y54, resolution 2.10Å" /> '''Crystal structure of...) |
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| - | [[Image:1y54.gif|left|200px]]<br /><applet load="1y54" size=" | + | [[Image:1y54.gif|left|200px]]<br /><applet load="1y54" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1y54, resolution 2.10Å" /> | caption="1y54, resolution 2.10Å" /> | ||
'''Crystal structure of the native class C beta-lactamase from Enterobacter cloacae 908R complexed with BRL42715'''<br /> | '''Crystal structure of the native class C beta-lactamase from Enterobacter cloacae 908R complexed with BRL42715'''<br /> | ||
==Overview== | ==Overview== | ||
| - | BRL 42715, C6-(N1-methyl-1,2,3-triazolylmethylene)penem, is an active-site-directed inactivator of bacterial -lactamases. The crystal structure of Enterobacter cloacae 908R class C -lactamase in complex with BRL 42715, docking, and energy minimization studies explain stereoselectivity of the binding of C6-(heterocyclic methylene)penems against class C -lactamase. | + | BRL 42715, C6-(N1-methyl-1,2,3-triazolylmethylene)penem, is an active-site-directed inactivator of bacterial beta-lactamases. The crystal structure of Enterobacter cloacae 908R class C beta-lactamase in complex with BRL 42715, docking, and energy minimization studies explain stereoselectivity of the binding of C6-(heterocyclic methylene)penems against class C beta-lactamase. |
==About this Structure== | ==About this Structure== | ||
| - | 1Y54 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacter_cloacae Enterobacter cloacae] with FDT as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] Full crystallographic information is available from [http:// | + | 1Y54 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacter_cloacae Enterobacter cloacae] with <scene name='pdbligand=FDT:'>FDT</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y54 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Charlier, P.]] | [[Category: Charlier, P.]] | ||
| - | [[Category: Frere, J | + | [[Category: Frere, J M.]] |
[[Category: Michaux, C.]] | [[Category: Michaux, C.]] | ||
[[Category: Wouters, J.]] | [[Category: Wouters, J.]] | ||
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[[Category: class c beta-lactamase]] | [[Category: class c beta-lactamase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:01:51 2008'' |
Revision as of 14:01, 21 February 2008
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Crystal structure of the native class C beta-lactamase from Enterobacter cloacae 908R complexed with BRL42715
Overview
BRL 42715, C6-(N1-methyl-1,2,3-triazolylmethylene)penem, is an active-site-directed inactivator of bacterial beta-lactamases. The crystal structure of Enterobacter cloacae 908R class C beta-lactamase in complex with BRL 42715, docking, and energy minimization studies explain stereoselectivity of the binding of C6-(heterocyclic methylene)penems against class C beta-lactamase.
About this Structure
1Y54 is a Single protein structure of sequence from Enterobacter cloacae with as ligand. Active as Beta-lactamase, with EC number 3.5.2.6 Full crystallographic information is available from OCA.
Reference
Crystal structure of BRL 42715, C6-(N1-methyl-1,2,3-triazolylmethylene)penem, in complex with Enterobacter cloacae 908R beta-lactamase: evidence for a stereoselective mechanism from docking studies., Michaux C, Charlier P, Frere JM, Wouters J, J Am Chem Soc. 2005 Mar 16;127(10):3262-3. PMID:15755127
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