1y6e
From Proteopedia
(New page: 200px<br /><applet load="1y6e" size="450" color="white" frame="true" align="right" spinBox="true" caption="1y6e, resolution 3.0Å" /> '''Orthorhombic glutathi...) |
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| - | [[Image:1y6e.gif|left|200px]]<br /><applet load="1y6e" size=" | + | [[Image:1y6e.gif|left|200px]]<br /><applet load="1y6e" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1y6e, resolution 3.0Å" /> | caption="1y6e, resolution 3.0Å" /> | ||
'''Orthorhombic glutathione S-transferase of Schistosoma japonicum'''<br /> | '''Orthorhombic glutathione S-transferase of Schistosoma japonicum'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The crystal structure of the 26 kDa glutathione S-transferase from | + | The crystal structure of the 26 kDa glutathione S-transferase from Schistosoma japonicum (SjGST) was determined at 3 A resolution in the new space group P2(1)2(1)2(1). The structure of orthorhombic SjGST reveals unique features of the ligand-binding site and dimer interface when compared with previously reported structures. SjGST is recognized as the major detoxification enzyme of S. japonicum, a pathogenic helminth causing schistosomiasis. As resistance against the established inhibitor of SjGST, praziquantel, has been reported these results might prove to be valuable for the development of novel drugs. |
==About this Structure== | ==About this Structure== | ||
| - | 1Y6E is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Schistosoma_japonicum Schistosoma japonicum]. Active as [http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] Full crystallographic information is available from [http:// | + | 1Y6E is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Schistosoma_japonicum Schistosoma japonicum]. Active as [http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y6E OCA]. |
==Reference== | ==Reference== | ||
| - | X-ray structure of glutathione S-transferase from Schistosoma japonicum in a new crystal form reveals flexibility of the substrate-binding site., Rufer AC, Thiebach L, Baer K, Klein HW, Hennig M, Acta | + | X-ray structure of glutathione S-transferase from Schistosoma japonicum in a new crystal form reveals flexibility of the substrate-binding site., Rufer AC, Thiebach L, Baer K, Klein HW, Hennig M, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Mar 1;61(Pt, 3):263-5. Epub 2005 Feb 24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16511012 16511012] |
[[Category: Glutathione transferase]] | [[Category: Glutathione transferase]] | ||
[[Category: Schistosoma japonicum]] | [[Category: Schistosoma japonicum]] | ||
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[[Category: Baer, K.]] | [[Category: Baer, K.]] | ||
[[Category: Hennig, M.]] | [[Category: Hennig, M.]] | ||
| - | [[Category: Klein, H | + | [[Category: Klein, H W.]] |
| - | [[Category: Rufer, A | + | [[Category: Rufer, A C.]] |
[[Category: Thiebach, L.]] | [[Category: Thiebach, L.]] | ||
[[Category: dimer]] | [[Category: dimer]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:02:11 2008'' |
Revision as of 14:02, 21 February 2008
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Orthorhombic glutathione S-transferase of Schistosoma japonicum
Overview
The crystal structure of the 26 kDa glutathione S-transferase from Schistosoma japonicum (SjGST) was determined at 3 A resolution in the new space group P2(1)2(1)2(1). The structure of orthorhombic SjGST reveals unique features of the ligand-binding site and dimer interface when compared with previously reported structures. SjGST is recognized as the major detoxification enzyme of S. japonicum, a pathogenic helminth causing schistosomiasis. As resistance against the established inhibitor of SjGST, praziquantel, has been reported these results might prove to be valuable for the development of novel drugs.
About this Structure
1Y6E is a Single protein structure of sequence from Schistosoma japonicum. Active as Glutathione transferase, with EC number 2.5.1.18 Full crystallographic information is available from OCA.
Reference
X-ray structure of glutathione S-transferase from Schistosoma japonicum in a new crystal form reveals flexibility of the substrate-binding site., Rufer AC, Thiebach L, Baer K, Klein HW, Hennig M, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Mar 1;61(Pt, 3):263-5. Epub 2005 Feb 24. PMID:16511012
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