2bk5
From Proteopedia
(New page: 200px<br /> <applet load="2bk5" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bk5, resolution 1.83Å" /> '''HUMAN MONOAMINE OXI...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2BK5 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with FAD and ISN as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.4 1.4.3.4]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BK5 OCA]]. | + | 2BK5 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with FAD and ISN as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Amine_oxidase_(flavin-containing) Amine oxidase (flavin-containing)]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.4 1.4.3.4]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BK5 OCA]]. |
==Reference== | ==Reference== | ||
Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors., Hubalek F, Binda C, Khalil A, Li M, Mattevi A, Castagnoli N, Edmondson DE, J Biol Chem. 2005 Apr 22;280(16):15761-6. Epub 2005 Feb 14. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15710600 15710600] | Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors., Hubalek F, Binda C, Khalil A, Li M, Mattevi A, Castagnoli N, Edmondson DE, J Biol Chem. 2005 Apr 22;280(16):15761-6. Epub 2005 Feb 14. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15710600 15710600] | ||
| + | [[Category: Amine oxidase (flavin-containing)]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: transmembrane]] | [[Category: transmembrane]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:06:16 2007'' |
Revision as of 12:01, 30 October 2007
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HUMAN MONOAMINE OXIDASE B: I199F MUTANT IN COMPLEX WITH ISATIN
Overview
Several reversible inhibitors selective for human monoamine oxidase B (MAO, B) that do not inhibit MAO A have been described in the literature. The, following compounds: 8-(3-chlorostyryl)caffeine, 1,4-diphenyl-2-butene, and trans,trans-farnesol are shown to inhibit competitively human, horse, rat, and mouse MAO B with K(i) values in the low micromolar range but are, without effect on either bovine or sheep MAO B or human MAO A. In, contrast, the reversible competitive inhibitor isatin binds to all known, MAO B and MAO A with similar affinities. Sequence alignments and the, crystal structures of human MAO B in complex with 1,4-diphenyl-2-butene or, with trans,trans-farnesol provide molecular insights into these, specificities. These inhibitors span the substrate and entrance cavities, ... [(full description)]
About this Structure
2BK5 is a [Single protein] structure of sequence from [Homo sapiens] with FAD and ISN as [ligands]. Active as [Amine oxidase (flavin-containing)], with EC number [1.4.3.4]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors., Hubalek F, Binda C, Khalil A, Li M, Mattevi A, Castagnoli N, Edmondson DE, J Biol Chem. 2005 Apr 22;280(16):15761-6. Epub 2005 Feb 14. PMID:15710600
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