1uol
From Proteopedia
(Difference between revisions)
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[[Image:1uol.png|left|200px]] | [[Image:1uol.png|left|200px]] | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | [[1uol]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UOL OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:14534297</ref><references group="xtra"/> | + | <ref group="xtra">PMID:14534297</ref><ref group="xtra">PMID:9843948</ref><ref group="xtra">PMID:8023157</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Allen, M D.]] | [[Category: Allen, M D.]] | ||
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[[Category: Apoptosis]] | [[Category: Apoptosis]] | ||
[[Category: Dna-binding domain]] | [[Category: Dna-binding domain]] | ||
| + | [[Category: Dna-binding protein]] | ||
[[Category: P53]] | [[Category: P53]] | ||
[[Category: Second-site suppressor mutation]] | [[Category: Second-site suppressor mutation]] | ||
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[[Category: Transcription regulation]] | [[Category: Transcription regulation]] | ||
[[Category: Tumor suppressor]] | [[Category: Tumor suppressor]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 16:53:31 2009'' | ||
Revision as of 21:38, 14 March 2011
CRYSTAL STRUCTURE OF THE HUMAN P53 CORE DOMAIN MUTANT M133L/V203A/N239Y/N268D AT 1.9 A RESOLUTION.
Template:ABSTRACT PUBMED 14534297
About this Structure
1uol is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Joerger AC, Allen MD, Fersht AR. Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations. J Biol Chem. 2004 Jan 9;279(2):1291-6. Epub 2003 Oct 8. PMID:14534297 doi:10.1074/jbc.M309732200
- Nikolova PV, Henckel J, Lane DP, Fersht AR. Semirational design of active tumor suppressor p53 DNA binding domain with enhanced stability. Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14675-80. PMID:9843948
- Cho Y, Gorina S, Jeffrey PD, Pavletich NP. Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. Science. 1994 Jul 15;265(5170):346-55. PMID:8023157
