1bk9
From Proteopedia
(New page: 200px<br /> <applet load="1bk9" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bk9, resolution 2.00Å" /> '''PHOSPHOLIPASE A2 MO...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1BK9 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Gloydius_halys Gloydius halys]] with CA, PBP and BU1 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BK9 OCA]]. | + | 1BK9 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Gloydius_halys Gloydius halys]] with CA, PBP and BU1 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4]]. Structure known Active Site: PBP. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BK9 OCA]]. |
==Reference== | ==Reference== | ||
Structure of a snake venom phospholipase A2 modified by p-bromo-phenacyl-bromide., Zhao H, Tang L, Wang X, Zhou Y, Lin Z, Toxicon. 1998 Jun;36(6):875-86. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9663694 9663694] | Structure of a snake venom phospholipase A2 modified by p-bromo-phenacyl-bromide., Zhao H, Tang L, Wang X, Zhou Y, Lin Z, Toxicon. 1998 Jun;36(6):875-86. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9663694 9663694] | ||
[[Category: Gloydius halys]] | [[Category: Gloydius halys]] | ||
| + | [[Category: Phospholipase A(2)]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Lin, Z.]] | [[Category: Lin, Z.]] | ||
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[[Category: platelet aggregation inhibitor]] | [[Category: platelet aggregation inhibitor]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:06:55 2007'' |
Revision as of 12:02, 30 October 2007
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PHOSPHOLIPASE A2 MODIFIED BY PBPB
Overview
The crystal structure of acidic phospholipase A2 (APLA2) from Agkistrodon, halys pallas covalently modified by p-bromo-phenacyl-bromide (pBPB) was, determined to a resolution of 2.0 A by an isomorphous difference Fourier, method with the native APLA2 structure as an initial model and refined to, a crystallographic R factor of 15.3%. The modified APLA2 structure is, remarkably similar to that of the native one. Least-squares superposition, of C alpha atoms of native and modified APLA2 results in a, root-mean-square coordinate deviation of 0.243 A. The p-bromo-phenacyl, group near the active site occupies a position similar to that in pBPB, modified bovine pancreatic PLA2. The inhibitor covalently bound to the NDI, atom of His48 fits well in the hydrophobic channel, forming extensive, ... [(full description)]
About this Structure
1BK9 is a [Single protein] structure of sequence from [Gloydius halys] with CA, PBP and BU1 as [ligands]. Active as [Phospholipase A(2)], with EC number [3.1.1.4]. Structure known Active Site: PBP. Full crystallographic information is available from [OCA].
Reference
Structure of a snake venom phospholipase A2 modified by p-bromo-phenacyl-bromide., Zhao H, Tang L, Wang X, Zhou Y, Lin Z, Toxicon. 1998 Jun;36(6):875-86. PMID:9663694
Page seeded by OCA on Tue Oct 30 14:06:55 2007
Categories: Gloydius halys | Phospholipase A(2) | Single protein | Lin, Z. | Tang, L. | Wang, X. | Zhao, H. | Zhou, Y. | BU1 | CA | PBP | Hydrolase | Pbpb | Phospholipase a2 | Platelet aggregation inhibitor
