3bys

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[[Image:3bys.png|left|200px]]
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{{STRUCTURE_3bys| PDB=3bys | SCENE= }}
{{STRUCTURE_3bys| PDB=3bys | SCENE= }}
===co-crystal structure of Lck and aminopyrimidine amide 10b===
===co-crystal structure of Lck and aminopyrimidine amide 10b===
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{{ABSTRACT_PUBMED_18321037}}
{{ABSTRACT_PUBMED_18321037}}
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==Disease==
 
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Known disease associated with this structure: SCID due to LCK deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=153390 153390]]
 
==About this Structure==
==About this Structure==
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3BYS is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BYS OCA].
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[[3bys]] is a 1 chain structure of [[Proto-oncogene tyrosine-protein kinase]] and [[Tyrosine kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BYS OCA].
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==See Also==
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*[[Proto-oncogene tyrosine-protein kinase|Proto-oncogene tyrosine-protein kinase]]
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*[[Tyrosine kinase|Tyrosine kinase]]
==Reference==
==Reference==
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<ref group="xtra">PMID:18321037</ref><references group="xtra"/>
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<ref group="xtra">PMID:018321037</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific protein-tyrosine kinase]]
[[Category: Non-specific protein-tyrosine kinase]]
[[Category: Huang, X.]]
[[Category: Huang, X.]]
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[[Category: Alternative splicing]]
 
[[Category: Atp-binding]]
[[Category: Atp-binding]]
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[[Category: Chromosomal rearrangement]]
 
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[[Category: Cytoplasm]]
 
[[Category: Disease mutation]]
[[Category: Disease mutation]]
[[Category: Host-virus interaction]]
[[Category: Host-virus interaction]]
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[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Tyrosine-protein kinase]]
[[Category: Tyrosine-protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 16:59:31 2009''
 

Revision as of 18:21, 25 July 2012

Image:3bys.png

Template:STRUCTURE 3bys

Contents

co-crystal structure of Lck and aminopyrimidine amide 10b

Template:ABSTRACT PUBMED 18321037

About this Structure

3bys is a 1 chain structure of Proto-oncogene tyrosine-protein kinase and Tyrosine kinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • DiMauro EF, Newcomb J, Nunes JJ, Bemis JE, Boucher C, Chai L, Chaffee SC, Deak HL, Epstein LF, Faust T, Gallant P, Gore A, Gu Y, Henkle B, Hsieh F, Huang X, Kim JL, Lee JH, Martin MW, McGowan DC, Metz D, Mohn D, Morgenstern KA, Oliveira-dos-Santos A, Patel VF, Powers D, Rose PE, Schneider S, Tomlinson SA, Tudor YY, Turci SM, Welcher AA, Zhao H, Zhu L, Zhu X. Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation. J Med Chem. 2008 Mar 27;51(6):1681-94. Epub 2008 Mar 6. PMID:18321037 doi:10.1021/jm7010996

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OCA

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