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1ymf

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(New page: 200px<br /><applet load="1ymf" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ymf, resolution 2.6&Aring;" /> '''crystal structure of ...)
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[[Image:1ymf.gif|left|200px]]<br /><applet load="1ymf" size="450" color="white" frame="true" align="right" spinBox="true"
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[[Image:1ymf.gif|left|200px]]<br /><applet load="1ymf" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1ymf, resolution 2.6&Aring;" />
caption="1ymf, resolution 2.6&Aring;" />
'''crystal structure of yellow fever virus NS3 helicase complexed with ADP'''<br />
'''crystal structure of yellow fever virus NS3 helicase complexed with ADP'''<br />
==Overview==
==Overview==
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Yellow fever virus (YFV), a member of the Flavivirus genus, has a, plus-sense RNA genome encoding a single polyprotein. Viral protein NS3, includes a protease and a helicase that are essential to virus replication, and to RNA capping. The 1.8-A crystal structure of the helicase region of, the YFV NS3 protein includes residues 187 to 623. Two familiar helicase, domains bind nucleotide in a triphosphate pocket without base recognition, providing a site for nonspecific hydrolysis of nucleoside triphosphates, and RNA triphosphate. The third, C-terminal domain has a unique structure, and is proposed to function in RNA and protein recognition. The, organization of the three domains indicates that cleavage of the viral, polyprotein NS3-NS4A junction occurs in trans.
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Yellow fever virus (YFV), a member of the Flavivirus genus, has a plus-sense RNA genome encoding a single polyprotein. Viral protein NS3 includes a protease and a helicase that are essential to virus replication and to RNA capping. The 1.8-A crystal structure of the helicase region of the YFV NS3 protein includes residues 187 to 623. Two familiar helicase domains bind nucleotide in a triphosphate pocket without base recognition, providing a site for nonspecific hydrolysis of nucleoside triphosphates and RNA triphosphate. The third, C-terminal domain has a unique structure and is proposed to function in RNA and protein recognition. The organization of the three domains indicates that cleavage of the viral polyprotein NS3-NS4A junction occurs in trans.
==About this Structure==
==About this Structure==
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1YMF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Yellow_fever_virus Yellow fever virus] with ADP as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1YMF OCA].
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1YMF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Yellow_fever_virus Yellow fever virus] with <scene name='pdbligand=ADP:'>ADP</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YMF OCA].
==Reference==
==Reference==
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Yellow fever virus]]
[[Category: Yellow fever virus]]
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[[Category: Bera, A.K.]]
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[[Category: Bera, A K.]]
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[[Category: Kuhn, R.J.]]
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[[Category: Kuhn, R J.]]
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[[Category: Smith, J.L.]]
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[[Category: Smith, J L.]]
[[Category: Wu, J.]]
[[Category: Wu, J.]]
[[Category: ADP]]
[[Category: ADP]]
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[[Category: yellow fever virus]]
[[Category: yellow fever virus]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 06:54:39 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:06:48 2008''

Revision as of 14:06, 21 February 2008

Image:1ymf.gif

1ymf, resolution 2.6Å

Drag the structure with the mouse to rotate

crystal structure of yellow fever virus NS3 helicase complexed with ADP

Overview

Yellow fever virus (YFV), a member of the Flavivirus genus, has a plus-sense RNA genome encoding a single polyprotein. Viral protein NS3 includes a protease and a helicase that are essential to virus replication and to RNA capping. The 1.8-A crystal structure of the helicase region of the YFV NS3 protein includes residues 187 to 623. Two familiar helicase domains bind nucleotide in a triphosphate pocket without base recognition, providing a site for nonspecific hydrolysis of nucleoside triphosphates and RNA triphosphate. The third, C-terminal domain has a unique structure and is proposed to function in RNA and protein recognition. The organization of the three domains indicates that cleavage of the viral polyprotein NS3-NS4A junction occurs in trans.

About this Structure

1YMF is a Single protein structure of sequence from Yellow fever virus with as ligand. Full crystallographic information is available from OCA.

Reference

Structure of the Flavivirus helicase: implications for catalytic activity, protein interactions, and proteolytic processing., Wu J, Bera AK, Kuhn RJ, Smith JL, J Virol. 2005 Aug;79(16):10268-77. PMID:16051820

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