1ypy
From Proteopedia
(New page: 200px<br /><applet load="1ypy" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ypy, resolution 1.510Å" /> '''Crystal Structure o...) |
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| - | [[Image:1ypy.gif|left|200px]]<br /><applet load="1ypy" size=" | + | [[Image:1ypy.gif|left|200px]]<br /><applet load="1ypy" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1ypy, resolution 1.510Å" /> | caption="1ypy, resolution 1.510Å" /> | ||
'''Crystal Structure of Vaccinia Virus L1 protein'''<br /> | '''Crystal Structure of Vaccinia Virus L1 protein'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Although eradicated from nature more than two decades ago, the threat of | + | Although eradicated from nature more than two decades ago, the threat of smallpox has reemerged because of concerns over its use as a biological weapon. We present the structure of the poxvirus L1 protein, a molecule that is conserved throughout the poxvirus family and is nearly identical in vaccinia virus and in variola virus, which causes smallpox. L1 is a myristoylated envelope protein that is a potent target for neutralizing antibodies and an important component of current experimental vaccines. The L1 structure reveals a hydrophobic cavity located adjacent to its N terminus. The cavity would be capable of shielding the myristate moiety, which is essential for virion assembly. The structure of L1 is a step in the elucidation of molecular mechanisms common to all poxviruses that may stimulate the design of safer vaccines and new antipoxvirus drugs. |
==About this Structure== | ==About this Structure== | ||
| - | 1YPY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http:// | + | 1YPY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YPY OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Vaccinia virus]] | [[Category: Vaccinia virus]] | ||
| - | [[Category: Allison, T | + | [[Category: Allison, T J.]] |
[[Category: Fogg, C.]] | [[Category: Fogg, C.]] | ||
| - | [[Category: Garboczi, D | + | [[Category: Garboczi, D N.]] |
| - | [[Category: Garman, S | + | [[Category: Garman, S C.]] |
[[Category: Moss, B.]] | [[Category: Moss, B.]] | ||
| - | [[Category: Su, H | + | [[Category: Su, H P.]] |
[[Category: l1]] | [[Category: l1]] | ||
[[Category: orthopox]] | [[Category: orthopox]] | ||
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[[Category: variola virus]] | [[Category: variola virus]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:07:53 2008'' |
Revision as of 14:07, 21 February 2008
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Crystal Structure of Vaccinia Virus L1 protein
Overview
Although eradicated from nature more than two decades ago, the threat of smallpox has reemerged because of concerns over its use as a biological weapon. We present the structure of the poxvirus L1 protein, a molecule that is conserved throughout the poxvirus family and is nearly identical in vaccinia virus and in variola virus, which causes smallpox. L1 is a myristoylated envelope protein that is a potent target for neutralizing antibodies and an important component of current experimental vaccines. The L1 structure reveals a hydrophobic cavity located adjacent to its N terminus. The cavity would be capable of shielding the myristate moiety, which is essential for virion assembly. The structure of L1 is a step in the elucidation of molecular mechanisms common to all poxviruses that may stimulate the design of safer vaccines and new antipoxvirus drugs.
About this Structure
1YPY is a Single protein structure of sequence from Vaccinia virus. Full crystallographic information is available from OCA.
Reference
The 1.51-Angstrom structure of the poxvirus L1 protein, a target of potent neutralizing antibodies., Su HP, Garman SC, Allison TJ, Fogg C, Moss B, Garboczi DN, Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4240-5. Epub 2005 Mar 10. PMID:15761054
Page seeded by OCA on Thu Feb 21 16:07:53 2008
Categories: Single protein | Vaccinia virus | Allison, T J. | Fogg, C. | Garboczi, D N. | Garman, S C. | Moss, B. | Su, H P. | L1 | Orthopox | Smallpox | Variola virus
