1yv3
From Proteopedia
(New page: 200px<br /><applet load="1yv3" size="450" color="white" frame="true" align="right" spinBox="true" caption="1yv3, resolution 2.0Å" /> '''The structural basis ...) |
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| - | [[Image:1yv3.gif|left|200px]]<br /><applet load="1yv3" size=" | + | [[Image:1yv3.gif|left|200px]]<br /><applet load="1yv3" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1yv3, resolution 2.0Å" /> | caption="1yv3, resolution 2.0Å" /> | ||
'''The structural basis of blebbistatin inhibition and specificity for myosin II'''<br /> | '''The structural basis of blebbistatin inhibition and specificity for myosin II'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Molecular motors play a central role in cytoskeletal-mediated cellular | + | Molecular motors play a central role in cytoskeletal-mediated cellular processes and thus present an excellent target for cellular control by pharmacological agents. Yet very few such compounds have been found. We report here the structure of blebbistatin, which inhibits specific myosin isoforms, bound to the motor domain of Dictyostelium discoideum myosin II. This reveals the structural basis for its specificity and provides insight into the development of new agents. |
==About this Structure== | ==About this Structure== | ||
| - | 1YV3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum] with MG, VO4, ADP, BIT and EDO as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1YV3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=VO4:'>VO4</scene>, <scene name='pdbligand=ADP:'>ADP</scene>, <scene name='pdbligand=BIT:'>BIT</scene> and <scene name='pdbligand=EDO:'>EDO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YV3 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Dictyostelium discoideum]] | [[Category: Dictyostelium discoideum]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Allingham, J | + | [[Category: Allingham, J S.]] |
[[Category: Rayment, I.]] | [[Category: Rayment, I.]] | ||
[[Category: Smith, R.]] | [[Category: Smith, R.]] | ||
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[[Category: myosin-inhibitor complex]] | [[Category: myosin-inhibitor complex]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:09:22 2008'' |
Revision as of 14:09, 21 February 2008
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The structural basis of blebbistatin inhibition and specificity for myosin II
Overview
Molecular motors play a central role in cytoskeletal-mediated cellular processes and thus present an excellent target for cellular control by pharmacological agents. Yet very few such compounds have been found. We report here the structure of blebbistatin, which inhibits specific myosin isoforms, bound to the motor domain of Dictyostelium discoideum myosin II. This reveals the structural basis for its specificity and provides insight into the development of new agents.
About this Structure
1YV3 is a Single protein structure of sequence from Dictyostelium discoideum with , , , and as ligands. Full crystallographic information is available from OCA.
Reference
The structural basis of blebbistatin inhibition and specificity for myosin II., Allingham JS, Smith R, Rayment I, Nat Struct Mol Biol. 2005 Apr;12(4):378-9. Epub 2005 Mar 6. PMID:15750603
Page seeded by OCA on Thu Feb 21 16:09:22 2008
Categories: Dictyostelium discoideum | Single protein | Allingham, J S. | Rayment, I. | Smith, R. | ADP | BIT | EDO | MG | VO4 | Blebbistatin | Metastable state | Myosin | Myosin ii inhibitor | Myosin-inhibitor complex
