2ghv

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[[Image:2ghv.png|left|200px]]
 
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{{STRUCTURE_2ghv| PDB=2ghv | SCENE= }}
{{STRUCTURE_2ghv| PDB=2ghv | SCENE= }}
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===Crystal structure of SARS spike protein receptor binding domain===
===Crystal structure of SARS spike protein receptor binding domain===
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{{ABSTRACT_PUBMED_16954221}}
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==Function==
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[[http://www.uniprot.org/uniprot/SPIKE_CVHSA SPIKE_CVHSA]] S1 attaches the virion to the cell membrane by interacting with human ACE2 and CLEC4M/DC-SIGNR, initiating the infection. Binding to the receptor and internalization of the virus into the endosomes of the host cell probably induces conformational changes in the S glycoprotein. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes. S2 is a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.
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{{ABSTRACT_PUBMED_16954221}}
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==About this Structure==
==About this Structure==
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2GHV is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Human_sars_coronavirus Human sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GHV OCA].
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[[2ghv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GHV OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:16954221</ref><references group="xtra"/>
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<ref group="xtra">PMID:016954221</ref><references group="xtra"/><references/>
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[[Category: Human sars coronavirus]]
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[[Category: Sars coronavirus]]
[[Category: Farzan, M.]]
[[Category: Farzan, M.]]
[[Category: Hwang, W C.]]
[[Category: Hwang, W C.]]
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[[Category: S protein]]
[[Category: S protein]]
[[Category: Sar]]
[[Category: Sar]]
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[[Category: Viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:16:03 2009''
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Revision as of 08:16, 23 April 2014

Template:STRUCTURE 2ghv

Contents

Crystal structure of SARS spike protein receptor binding domain

Template:ABSTRACT PUBMED 16954221

Function

[SPIKE_CVHSA] S1 attaches the virion to the cell membrane by interacting with human ACE2 and CLEC4M/DC-SIGNR, initiating the infection. Binding to the receptor and internalization of the virus into the endosomes of the host cell probably induces conformational changes in the S glycoprotein. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes. S2 is a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.

About this Structure

2ghv is a 2 chain structure with sequence from Sars coronavirus. Full crystallographic information is available from OCA.

Reference

  • Hwang WC, Lin Y, Santelli E, Sui J, Jaroszewski L, Stec B, Farzan M, Marasco WA, Liddington RC. Structural basis of neutralization by a human anti-severe acute respiratory syndrome spike protein antibody, 80R. J Biol Chem. 2006 Nov 10;281(45):34610-6. Epub 2006 Sep 5. PMID:16954221 doi:10.1074/jbc.M603275200

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