This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2vip
From Proteopedia
| Line 1: | Line 1: | ||
| - | {{Seed}} | ||
[[Image:2vip.png|left|200px]] | [[Image:2vip.png|left|200px]] | ||
| - | <!-- | ||
| - | The line below this paragraph, containing "STRUCTURE_2vip", creates the "Structure Box" on the page. | ||
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet) | ||
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| - | or leave the SCENE parameter empty for the default display. | ||
| - | --> | ||
{{STRUCTURE_2vip| PDB=2vip | SCENE= }} | {{STRUCTURE_2vip| PDB=2vip | SCENE= }} | ||
===FRAGMENT-BASED DISCOVERY OF MEXILETINE DERIVATIVES AS ORALLY BIOAVAILABLE INHIBITORS OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR=== | ===FRAGMENT-BASED DISCOVERY OF MEXILETINE DERIVATIVES AS ORALLY BIOAVAILABLE INHIBITORS OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR=== | ||
| - | |||
| - | <!-- | ||
| - | The line below this paragraph, {{ABSTRACT_PUBMED_18163548}}, adds the Publication Abstract to the page | ||
| - | (as it appears on PubMed at http://www.pubmed.gov), where 18163548 is the PubMed ID number. | ||
| - | --> | ||
{{ABSTRACT_PUBMED_18163548}} | {{ABSTRACT_PUBMED_18163548}} | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[2vip]] is a 1 chain structure of [[Urokinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VIP OCA]. | |
| + | |||
| + | ==See Also== | ||
| + | *[[Urokinase|Urokinase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:018163548</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: U-plasminogen activator]] | [[Category: U-plasminogen activator]] | ||
| Line 43: | Line 34: | ||
[[Category: Inhibitor]] | [[Category: Inhibitor]] | ||
[[Category: Kringle]] | [[Category: Kringle]] | ||
| - | [[Category: Pharmaceutical]] | ||
[[Category: Phosphorylation]] | [[Category: Phosphorylation]] | ||
[[Category: Plasminogen activation]] | [[Category: Plasminogen activation]] | ||
| - | [[Category: Polymorphism]] | ||
[[Category: Protease]] | [[Category: Protease]] | ||
[[Category: Secreted]] | [[Category: Secreted]] | ||
| Line 52: | Line 41: | ||
[[Category: Urokinase-type plasminogen activator]] | [[Category: Urokinase-type plasminogen activator]] | ||
[[Category: Zymogen]] | [[Category: Zymogen]] | ||
| - | |||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:17:49 2009'' | ||
Revision as of 20:22, 25 July 2012
Contents |
FRAGMENT-BASED DISCOVERY OF MEXILETINE DERIVATIVES AS ORALLY BIOAVAILABLE INHIBITORS OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR
Template:ABSTRACT PUBMED 18163548
About this Structure
2vip is a 1 chain structure of Urokinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Frederickson M, Callaghan O, Chessari G, Congreve M, Cowan SR, Matthews JE, McMenamin R, Smith DM, Vinkovic M, Wallis NG. Fragment-based discovery of mexiletine derivatives as orally bioavailable inhibitors of urokinase-type plasminogen activator. J Med Chem. 2008 Jan 24;51(2):183-6. Epub 2007 Dec 29. PMID:18163548 doi:http://dx.doi.org/10.1021/jm701359z
Categories: Homo sapiens | U-plasminogen activator | Callaghan, O. | Chessari, G. | Congreve, M. | Cowan, S R. | Frederickson, M. | Matthews, J E. | Mcmenamin, R. | Smith, D. | Vinkovic, M. | Wallis, N G. | Blood coagulation | Egf-like domain | Fibrinolysis | Glycoprotein | Hydrolase | Inhibitor | Kringle | Phosphorylation | Plasminogen activation | Protease | Secreted | Serine protease | Urokinase-type plasminogen activator | Zymogen
