1oh3
From Proteopedia
(New page: 200px<br /> <applet load="1oh3" size="450" color="white" frame="true" align="right" spinBox="true" caption="1oh3, resolution 1.50Å" /> '''E78R MUTANT OF A CA...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1OH3 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Piromyces_equi Piromyces equi]] with GLC as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OH3 OCA]]. | + | 1OH3 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Piromyces_equi Piromyces equi]] with GLC as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OH3 OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: ncp1]] | [[Category: ncp1]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:08:08 2007'' |
Revision as of 12:03, 30 October 2007
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E78R MUTANT OF A CARBOHYDRATE BINDING MODULE FAMILY 29
Overview
The structural and thermodynamic basis for carbohydrate-protein, recognition is of considerable importance. NCP-1, which is a component of, the Piromyces equi cellulase/hemicellulase complex, presents a provocative, model for analyzing how structural and mutational changes can influence, the ligand specificity of carbohydrate-binding proteins. NCP-1 contains, two "family 29" carbohydrate-binding modules designated CBM29-1 and, CBM29-2, respectively, that display unusually broad specificity; the, proteins interact weakly with xylan, exhibit moderate affinity for, cellulose and mannan, and bind tightly to the beta-1,4-linked, glucose-mannose heteropolymer glucomannan. The crystal structure of, CBM29-2 in complex with cellohexaose and mannohexaose identified key, residues involved in ligand ... [(full description)]
About this Structure
1OH3 is a [Single protein] structure of sequence from [Piromyces equi] with GLC as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Ligand-mediated dimerization of a carbohydrate-binding molecule reveals a novel mechanism for protein-carbohydrate recognition., Flint J, Nurizzo D, Harding SE, Longman E, Davies GJ, Gilbert HJ, Bolam DN, J Mol Biol. 2004 Mar 19;337(2):417-26. PMID:15003456
Page seeded by OCA on Tue Oct 30 14:08:08 2007
