1z0r
From Proteopedia
(New page: 200px<br /><applet load="1z0r" size="450" color="white" frame="true" align="right" spinBox="true" caption="1z0r" /> '''Solution Structure of the N-terminal DNA Rec...) |
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'''Solution Structure of the N-terminal DNA Recognition Domain of the Bacillus subtilis Transcription-State Regulator AbrB'''<br /> | '''Solution Structure of the N-terminal DNA Recognition Domain of the Bacillus subtilis Transcription-State Regulator AbrB'''<br /> | ||
==Overview== | ==Overview== | ||
| - | New relationships found in the process of updating the structural | + | New relationships found in the process of updating the structural classification of proteins (SCOP) database resulted in the revision of the structure of the N-terminal, DNA-binding domain of the transition state regulator AbrB. The dimeric AbrB domain shares a common fold with the addiction antidote MazE and the subunit of uncharacterized protein MraZ implicated in cell division and cell envelope formation. It has a detectable sequence similarity to both MazE and MraZ thus providing an evolutionary link between the two proteins. The putative DNA-binding site of AbrB is found on the same face as the DNA-binding site of MazE and appears similar, both in structure and sequence, to the exposed conserved region of MraZ. This strongly suggests that MraZ also binds DNA and allows for a consensus model of DNA recognition by the members of this novel protein superfamily. |
==About this Structure== | ==About this Structure== | ||
| - | 1Z0R is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. This structure | + | 1Z0R is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. This structure supersedes the now removed PDB entry 1EKT. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z0R OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Andreeva, A.]] | [[Category: Andreeva, A.]] | ||
| - | [[Category: Bobay, B | + | [[Category: Bobay, B G.]] |
[[Category: Cavanagh, J.]] | [[Category: Cavanagh, J.]] | ||
| - | [[Category: Mueller, G | + | [[Category: Mueller, G A.]] |
| - | [[Category: Murzin, A | + | [[Category: Murzin, A G.]] |
[[Category: n-terminal dna-binding domain]] | [[Category: n-terminal dna-binding domain]] | ||
[[Category: scop database]] | [[Category: scop database]] | ||
[[Category: transition state regulator]] | [[Category: transition state regulator]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:11:01 2008'' |
Revision as of 14:11, 21 February 2008
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Solution Structure of the N-terminal DNA Recognition Domain of the Bacillus subtilis Transcription-State Regulator AbrB
Overview
New relationships found in the process of updating the structural classification of proteins (SCOP) database resulted in the revision of the structure of the N-terminal, DNA-binding domain of the transition state regulator AbrB. The dimeric AbrB domain shares a common fold with the addiction antidote MazE and the subunit of uncharacterized protein MraZ implicated in cell division and cell envelope formation. It has a detectable sequence similarity to both MazE and MraZ thus providing an evolutionary link between the two proteins. The putative DNA-binding site of AbrB is found on the same face as the DNA-binding site of MazE and appears similar, both in structure and sequence, to the exposed conserved region of MraZ. This strongly suggests that MraZ also binds DNA and allows for a consensus model of DNA recognition by the members of this novel protein superfamily.
About this Structure
1Z0R is a Single protein structure of sequence from Bacillus subtilis. This structure supersedes the now removed PDB entry 1EKT. Full crystallographic information is available from OCA.
Reference
Revised structure of the AbrB N-terminal domain unifies a diverse superfamily of putative DNA-binding proteins., Bobay BG, Andreeva A, Mueller GA, Cavanagh J, Murzin AG, FEBS Lett. 2005 Oct 24;579(25):5669-74. Epub 2005 Oct 4. PMID:16223496
Page seeded by OCA on Thu Feb 21 16:11:01 2008
