This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2j21
From Proteopedia
| Line 1: | Line 1: | ||
| - | {{Seed}} | ||
[[Image:2j21.png|left|200px]] | [[Image:2j21.png|left|200px]] | ||
| Line 20: | Line 19: | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[2j21]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J21 OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:17015838</ref><references group="xtra"/> | + | <ref group="xtra">PMID:17015838</ref><ref group="xtra">PMID:14534297</ref><ref group="xtra">PMID:15703170</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Fersht, A R.]] | [[Category: Fersht, A R.]] | ||
| Line 38: | Line 37: | ||
[[Category: Glycoprotein]] | [[Category: Glycoprotein]] | ||
[[Category: Host-virus interaction]] | [[Category: Host-virus interaction]] | ||
| + | [[Category: Li- fraumeni syndrome]] | ||
[[Category: Li-fraumeni syndrome]] | [[Category: Li-fraumeni syndrome]] | ||
[[Category: Metal-binding]] | [[Category: Metal-binding]] | ||
| Line 51: | Line 51: | ||
[[Category: Tumor suppressor]] | [[Category: Tumor suppressor]] | ||
[[Category: Zinc]] | [[Category: Zinc]] | ||
| - | |||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:58:16 2009'' | ||
Revision as of 20:59, 14 March 2011
HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-N239Y-N268D-R282W
Template:ABSTRACT PUBMED 17015838
About this Structure
2j21 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Joerger AC, Ang HC, Fersht AR. Structural basis for understanding oncogenic p53 mutations and designing rescue drugs. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61. Epub 2006 Oct 2. PMID:17015838
- Joerger AC, Allen MD, Fersht AR. Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations. J Biol Chem. 2004 Jan 9;279(2):1291-6. Epub 2003 Oct 8. PMID:14534297 doi:10.1074/jbc.M309732200
- Joerger AC, Ang HC, Veprintsev DB, Blair CM, Fersht AR. Structures of p53 cancer mutants and mechanism of rescue by second-site suppressor mutations. J Biol Chem. 2005 Apr 22;280(16):16030-7. Epub 2005 Feb 9. PMID:15703170 doi:http://dx.doi.org/10.1074/jbc.M500179200
Categories: Homo sapiens | Fersht, A R. | Joerger, A C. | Acetylation | Activator | Alternative splicing | Anti-oncogene | Apoptosis | Cell cycle | Disease mutation | Dna-binding | Dna-binding protein | Glycoprotein | Host-virus interaction | Li- fraumeni syndrome | Li-fraumeni syndrome | Metal-binding | Nuclear protein | P53 dna-binding domain | Phosphorylation | Polymorphism | Second-site suppressor mutation | Superstable mutant | Transcription | Transcription regulation | Transferase | Tumor suppressor | Zinc
