This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3bcj
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | {{Seed}} | ||
[[Image:3bcj.png|left|200px]] | [[Image:3bcj.png|left|200px]] | ||
| - | <!-- | ||
| - | The line below this paragraph, containing "STRUCTURE_3bcj", creates the "Structure Box" on the page. | ||
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet) | ||
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| - | or leave the SCENE parameter empty for the default display. | ||
| - | --> | ||
{{STRUCTURE_3bcj| PDB=3bcj | SCENE= }} | {{STRUCTURE_3bcj| PDB=3bcj | SCENE= }} | ||
===Crystal structure of Aldose Reductase complexed with 2S4R (Stereoisomer of Fidarestat, 2S4S) at 0.78 A=== | ===Crystal structure of Aldose Reductase complexed with 2S4R (Stereoisomer of Fidarestat, 2S4S) at 0.78 A=== | ||
| - | |||
| - | <!-- | ||
| - | The line below this paragraph, {{ABSTRACT_PUBMED_18284183}}, adds the Publication Abstract to the page | ||
| - | (as it appears on PubMed at http://www.pubmed.gov), where 18284183 is the PubMed ID number. | ||
| - | --> | ||
{{ABSTRACT_PUBMED_18284183}} | {{ABSTRACT_PUBMED_18284183}} | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3bcj]] is a 1 chain structure of [[Aldose Reductase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BCJ OCA]. | |
| + | |||
| + | ==See Also== | ||
| + | *[[Aldose Reductase|Aldose Reductase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:018284183</ref><references group="xtra"/> |
[[Category: Aldehyde reductase]] | [[Category: Aldehyde reductase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: El-Kabbani, O.]] | [[Category: El-Kabbani, O.]] | ||
[[Category: Zhao, H T.]] | [[Category: Zhao, H T.]] | ||
| - | [[Category: Acetylation]] | ||
[[Category: Aldo-keto reductase]] | [[Category: Aldo-keto reductase]] | ||
[[Category: Cataract]] | [[Category: Cataract]] | ||
| - | [[Category: Cytoplasm]] | ||
[[Category: Diabetes]] | [[Category: Diabetes]] | ||
[[Category: Drug design]] | [[Category: Drug design]] | ||
| Line 37: | Line 26: | ||
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
[[Category: Polyl pathway]] | [[Category: Polyl pathway]] | ||
| - | [[Category: Polymorphism]] | ||
| - | |||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:30:12 2009'' | ||
Revision as of 23:06, 25 July 2012
Contents |
Crystal structure of Aldose Reductase complexed with 2S4R (Stereoisomer of Fidarestat, 2S4S) at 0.78 A
Template:ABSTRACT PUBMED 18284183
About this Structure
3bcj is a 1 chain structure of Aldose Reductase with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Zhao HT, Hazemann I, Mitschler A, Carbone V, Joachimiak A, Ginell S, Podjarny A, El-Kabbani O. Unusual Binding Mode of the 2S4R Stereoisomer of the Potent Aldose Reductase Cyclic Imide Inhibitor Fidarestat (2S4S) in the 15 K Crystal Structure of the Ternary Complex Refined at 0.78 A Resolution: Implications for the Inhibition Mechanism. J Med Chem. 2008 Mar 13;51(5):1478-1481. Epub 2008 Feb 20. PMID:18284183 doi:10.1021/jm701514k
