1tb6
From Proteopedia
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[[Image:1tb6.png|left|200px]] | [[Image:1tb6.png|left|200px]] | ||
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===2.5A Crystal Structure of the Antithrombin-Thrombin-Heparin Ternary Complex=== | ===2.5A Crystal Structure of the Antithrombin-Thrombin-Heparin Ternary Complex=== | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: Dysprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]], Hyperprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]], Hypoprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[1tb6]] is a 3 chain structure of [[Antithrombin]] and [[Thrombin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TB6 OCA]. | |
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| + | ==See Also== | ||
| + | *[[Antithrombin|Antithrombin]] | ||
| + | *[[Thrombin|Thrombin]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:015311269</ref><ref group="xtra">PMID:016673263</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Thrombin]] | [[Category: Thrombin]] | ||
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[[Category: Li, W.]] | [[Category: Li, W.]] | ||
[[Category: Heparin]] | [[Category: Heparin]] | ||
| - | + | [[Category: Hydrolase-blood clotting complex]] | |
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Revision as of 02:25, 26 July 2012
Contents |
2.5A Crystal Structure of the Antithrombin-Thrombin-Heparin Ternary Complex
Template:ABSTRACT PUBMED 15311269
About this Structure
1tb6 is a 3 chain structure of Antithrombin and Thrombin with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Li W, Johnson DJ, Esmon CT, Huntington JA. Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin. Nat Struct Mol Biol. 2004 Sep;11(9):857-62. Epub 2004 Aug 15. PMID:15311269 doi:10.1038/nsmb811
- Bode W. The structure of thrombin: a janus-headed proteinase. Semin Thromb Hemost. 2006 Apr;32 Suppl 1:16-31. PMID:16673263 doi:10.1055/s-2006-939551
