2c1x
From Proteopedia
(New page: 200px<br /> <applet load="2c1x" size="450" color="white" frame="true" align="right" spinBox="true" caption="2c1x, resolution 1.90Å" /> '''STRUCTURE AND ACTIV...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2C1X is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Vitis_vinifera Vitis vinifera]] with UDP and B3P as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.91 2.4.1.91]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C1X OCA]]. | + | 2C1X is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Vitis_vinifera Vitis vinifera]] with UDP and B3P as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Flavonol_3-O-glucosyltransferase Flavonol 3-O-glucosyltransferase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.91 2.4.1.91]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C1X OCA]]. |
==Reference== | ==Reference== | ||
Structure of a flavonoid glucosyltransferase reveals the basis for plant natural product modification., Offen W, Martinez-Fleites C, Yang M, Kiat-Lim E, Davis BG, Tarling CA, Ford CM, Bowles DJ, Davies GJ, EMBO J. 2006 Mar 22;25(6):1396-405. Epub 2006 Feb 16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16482224 16482224] | Structure of a flavonoid glucosyltransferase reveals the basis for plant natural product modification., Offen W, Martinez-Fleites C, Yang M, Kiat-Lim E, Davis BG, Tarling CA, Ford CM, Bowles DJ, Davies GJ, EMBO J. 2006 Mar 22;25(6):1396-405. Epub 2006 Feb 16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16482224 16482224] | ||
| + | [[Category: Flavonol 3-O-glucosyltransferase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Vitis vinifera]] | [[Category: Vitis vinifera]] | ||
| Line 32: | Line 33: | ||
[[Category: wine]] | [[Category: wine]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:11:59 2007'' |
Revision as of 12:07, 30 October 2007
|
STRUCTURE AND ACTIVITY OF A FLAVONOID 3-O GLUCOSYLTRANSFERASE REVEALS THE BASIS FOR PLANT NATURAL PRODUCT MODIFICATION
Overview
Glycosylation is a key mechanism for orchestrating the bioactivity, metabolism and location of small molecules in living cells. In plants, a, large multigene family of glycosyltransferases is involved in these, processes, conjugating hormones, secondary metabolites, biotic and abiotic, environmental toxins, to impact directly on cellular homeostasis. The red, grape enzyme UDP-glucose:flavonoid 3-O-glycosyltransferase (VvGT1) is, responsible for the formation of anthocyanins, the health-promoting, compounds which, in planta, function as colourants determining flower and, fruit colour and are precursors for the formation of pigmented polymers in, red wine. We show that VvGT1 is active, in vitro, on a range of, flavonoids. VvGT1 is somewhat promiscuous with respect to donor sugar, ... [(full description)]
About this Structure
2C1X is a [Single protein] structure of sequence from [Vitis vinifera] with UDP and B3P as [ligands]. Active as [Flavonol 3-O-glucosyltransferase], with EC number [2.4.1.91]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structure of a flavonoid glucosyltransferase reveals the basis for plant natural product modification., Offen W, Martinez-Fleites C, Yang M, Kiat-Lim E, Davis BG, Tarling CA, Ford CM, Bowles DJ, Davies GJ, EMBO J. 2006 Mar 22;25(6):1396-405. Epub 2006 Feb 16. PMID:16482224
Page seeded by OCA on Tue Oct 30 14:11:59 2007
Categories: Flavonol 3-O-glucosyltransferase | Single protein | Vitis vinifera | Bowles, D.J. | Davies, G.J. | Davis, B.G. | Ford, C.M. | Kiat-Lim, E. | Martinez-Fleites, C. | Offen, W. | Tarling, C.A. | Yang, M. | B3P | UDP | Catalysis | Flavonoid | Glycosylation | Glycosyltransferase | Transferase | Wine
