3kiv

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[[Image:3kiv.png|left|200px]]
 
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{{STRUCTURE_3kiv| PDB=3kiv | SCENE= }}
{{STRUCTURE_3kiv| PDB=3kiv | SCENE= }}
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===RECOMBINANT KRINGLE IV-10/M66 VARIANT OF HUMAN APOLIPOPROTEIN(A)===
===RECOMBINANT KRINGLE IV-10/M66 VARIANT OF HUMAN APOLIPOPROTEIN(A)===
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{{ABSTRACT_PUBMED_10026282}}
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==Function==
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[[http://www.uniprot.org/uniprot/APOA_HUMAN APOA_HUMAN]] Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.<ref>PMID:2531657</ref>
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{{ABSTRACT_PUBMED_10026282}}
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==About this Structure==
==About this Structure==
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3KIV is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KIV OCA].
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[[3kiv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KIV OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:10026282</ref><references group="xtra"/>
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<ref group="xtra">PMID:010026282</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Mochalkin, I.]]
[[Category: Mochalkin, I.]]
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[[Category: Kringle]]
[[Category: Kringle]]
[[Category: Lysine binding site]]
[[Category: Lysine binding site]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 00:34:23 2009''
 

Revision as of 02:01, 4 April 2013

Template:STRUCTURE 3kiv

Contents

RECOMBINANT KRINGLE IV-10/M66 VARIANT OF HUMAN APOLIPOPROTEIN(A)

Template:ABSTRACT PUBMED 10026282

Function

[APOA_HUMAN] Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.[1]

About this Structure

3kiv is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Mochalkin I, Cheng B, Klezovitch O, Scanu AM, Tulinsky A. Recombinant kringle IV-10 modules of human apolipoprotein(a): structure, ligand binding modes, and biological relevance. Biochemistry. 1999 Feb 16;38(7):1990-8. PMID:10026282 doi:10.1021/bi9820558
  1. ↑ Salonen EM, Jauhiainen M, Zardi L, Vaheri A, Ehnholm C. Lipoprotein(a) binds to fibronectin and has serine proteinase activity capable of cleaving it. EMBO J. 1989 Dec 20;8(13):4035-40. PMID:2531657

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