2c1g
From Proteopedia
(New page: 200px<br /> <applet load="2c1g" size="450" color="white" frame="true" align="right" spinBox="true" caption="2c1g, resolution 1.75Å" /> '''STRUCTURE OF STREPT...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2C1G is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]] with ACT, ZN and PEG as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.33 3.5.1.33]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C1G OCA]]. | + | 2C1G is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]] with ACT, ZN and PEG as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/N-acetylglucosamine_deacetylase N-acetylglucosamine deacetylase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.33 3.5.1.33]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C1G OCA]]. |
==Reference== | ==Reference== | ||
Structure and metal-dependent mechanism of peptidoglycan deacetylase, a streptococcal virulence factor., Blair DE, Schuttelkopf AW, MacRae JI, van Aalten DM, Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15429-34. Epub 2005 Oct 12. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16221761 16221761] | Structure and metal-dependent mechanism of peptidoglycan deacetylase, a streptococcal virulence factor., Blair DE, Schuttelkopf AW, MacRae JI, van Aalten DM, Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15429-34. Epub 2005 Oct 12. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16221761 16221761] | ||
| + | [[Category: N-acetylglucosamine deacetylase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Streptococcus pneumoniae]] | [[Category: Streptococcus pneumoniae]] | ||
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[[Category: peptidoglycan deacetylase]] | [[Category: peptidoglycan deacetylase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:12:33 2007'' |
Revision as of 12:07, 30 October 2007
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STRUCTURE OF STREPTOCOCCUS PNEUMONIAE PEPTIDOGLYCAN DEACETYLASE (SPPGDA)
Overview
Streptococcus pneumoniae peptidoglycan GlcNAc deacetylase (SpPgdA), protects the Gram-positive bacterial cell wall from host lysozymes by, deacetylating peptidoglycan GlcNAc residues. Deletion of the pgda gene has, been shown to result in hypersensitivity to lysozyme and reduction of, infectivity in a mouse model. SpPgdA is a member of the family 4, carbohydrate esterases, for which little structural information exists, and no catalytic mechanism has yet been defined. Here we describe the, native crystal structure and product complexes of SpPgdA biochemical, characterization and mutagenesis. The structural data show that SpPgdA is, an elongated three-domain protein in the crystal. The structure, in, combination with mutagenesis, shows that SpPgdA is a metalloenzyme using a, His-His-Asp ... [(full description)]
About this Structure
2C1G is a [Single protein] structure of sequence from [Streptococcus pneumoniae] with ACT, ZN and PEG as [ligands]. Active as [N-acetylglucosamine deacetylase], with EC number [3.5.1.33]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structure and metal-dependent mechanism of peptidoglycan deacetylase, a streptococcal virulence factor., Blair DE, Schuttelkopf AW, MacRae JI, van Aalten DM, Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15429-34. Epub 2005 Oct 12. PMID:16221761
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