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2aoz
From Proteopedia
(New page: 200px<br /><applet load="2aoz" size="450" color="white" frame="true" align="right" spinBox="true" caption="2aoz, resolution 2.08Å" /> '''Crystal structure of...) |
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| - | [[Image:2aoz.gif|left|200px]]<br /><applet load="2aoz" size=" | + | [[Image:2aoz.gif|left|200px]]<br /><applet load="2aoz" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2aoz, resolution 2.08Å" /> | caption="2aoz, resolution 2.08Å" /> | ||
'''Crystal structure of the myotoxin-II from Atropoides nummifer venom'''<br /> | '''Crystal structure of the myotoxin-II from Atropoides nummifer venom'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Lys49 snake-venom phospholipase A2 (PLA2) homologues are highly myotoxic | + | Lys49 snake-venom phospholipase A2 (PLA2) homologues are highly myotoxic proteins which, although lacking catalytic activity, possess the ability to disrupt biological membranes, inducing significant muscle-tissue loss and permanent disability in severely envenomed patients. Since the structural basis for their toxic activity is still only partially understood, the structure of myotoxin II, a monomeric Lys49 PLA2 homologue from Atropoides nummifer, has been determined at 2.08 angstroms resolution and the anion-binding site has been characterized. |
==About this Structure== | ==About this Structure== | ||
| - | 2AOZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Atropoides_nummifer Atropoides nummifer] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 2AOZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Atropoides_nummifer Atropoides nummifer] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AOZ OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of myotoxin II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom., Murakami MT, Melo CC, Angulo Y, Lomonte B, Arni RK, Acta | + | Structure of myotoxin II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom., Murakami MT, Melo CC, Angulo Y, Lomonte B, Arni RK, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 May 1;62(Pt, 5):423-6. Epub 2006 Apr 12. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16682766 16682766] |
[[Category: Atropoides nummifer]] | [[Category: Atropoides nummifer]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Angulo, Y.]] | [[Category: Angulo, Y.]] | ||
| - | [[Category: Arni, R | + | [[Category: Arni, R K.]] |
[[Category: Lomonte, B.]] | [[Category: Lomonte, B.]] | ||
| - | [[Category: Melo, C | + | [[Category: Melo, C C.]] |
| - | [[Category: Murakami, M | + | [[Category: Murakami, M T.]] |
[[Category: SO4]] | [[Category: SO4]] | ||
[[Category: atropoides nummifer]] | [[Category: atropoides nummifer]] | ||
| Line 24: | Line 24: | ||
[[Category: x-ray diffration]] | [[Category: x-ray diffration]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:29:28 2008'' |
Revision as of 14:29, 21 February 2008
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Crystal structure of the myotoxin-II from Atropoides nummifer venom
Overview
Lys49 snake-venom phospholipase A2 (PLA2) homologues are highly myotoxic proteins which, although lacking catalytic activity, possess the ability to disrupt biological membranes, inducing significant muscle-tissue loss and permanent disability in severely envenomed patients. Since the structural basis for their toxic activity is still only partially understood, the structure of myotoxin II, a monomeric Lys49 PLA2 homologue from Atropoides nummifer, has been determined at 2.08 angstroms resolution and the anion-binding site has been characterized.
About this Structure
2AOZ is a Single protein structure of sequence from Atropoides nummifer with as ligand. Full crystallographic information is available from OCA.
Reference
Structure of myotoxin II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom., Murakami MT, Melo CC, Angulo Y, Lomonte B, Arni RK, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 May 1;62(Pt, 5):423-6. Epub 2006 Apr 12. PMID:16682766
Page seeded by OCA on Thu Feb 21 16:29:28 2008
