2avy
From Proteopedia
(New page: 200px<br /><applet load="2avy" size="450" color="white" frame="true" align="right" spinBox="true" caption="2avy, resolution 3.46Å" /> '''Crystal structure of...) |
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| - | [[Image:2avy.gif|left|200px]]<br /><applet load="2avy" size=" | + | [[Image:2avy.gif|left|200px]]<br /><applet load="2avy" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2avy, resolution 3.46Å" /> | caption="2avy, resolution 3.46Å" /> | ||
'''Crystal structure of the bacterial ribosome from Escherichia coli at 3.5 A resolution. This file contains the 30S subunit of one 70S ribosome. The entire crystal structure contains two 70S ribosomes and is described in remark 400.'''<br /> | '''Crystal structure of the bacterial ribosome from Escherichia coli at 3.5 A resolution. This file contains the 30S subunit of one 70S ribosome. The entire crystal structure contains two 70S ribosomes and is described in remark 400.'''<br /> | ||
==Overview== | ==Overview== | ||
| - | We describe two structures of the intact bacterial ribosome from | + | We describe two structures of the intact bacterial ribosome from Escherichia coli determined to a resolution of 3.5 angstroms by x-ray crystallography. These structures provide a detailed view of the interface between the small and large ribosomal subunits and the conformation of the peptidyl transferase center in the context of the intact ribosome. Differences between the two ribosomes reveal a high degree of flexibility between the head and the rest of the small subunit. Swiveling of the head of the small subunit observed in the present structures, coupled to the ratchet-like motion of the two subunits observed previously, suggests a mechanism for the final movements of messenger RNA (mRNA) and transfer RNAs (tRNAs) during translocation. |
==About this Structure== | ==About this Structure== | ||
| - | 2AVY is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with MG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 2AVY is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=MG:'>MG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AVY OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Borovinskaya, M | + | [[Category: Borovinskaya, M A.]] |
| - | [[Category: Cate, J | + | [[Category: Cate, J H.D.]] |
| - | [[Category: Hau, C | + | [[Category: Hau, C W.]] |
| - | [[Category: Holton, J | + | [[Category: Holton, J M.]] |
| - | [[Category: Schuwirth, B | + | [[Category: Schuwirth, B S.]] |
[[Category: Vila-Sanjurjo, A.]] | [[Category: Vila-Sanjurjo, A.]] | ||
[[Category: Zhang, W.]] | [[Category: Zhang, W.]] | ||
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[[Category: rna-protein complex]] | [[Category: rna-protein complex]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:31:30 2008'' |
Revision as of 14:31, 21 February 2008
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Crystal structure of the bacterial ribosome from Escherichia coli at 3.5 A resolution. This file contains the 30S subunit of one 70S ribosome. The entire crystal structure contains two 70S ribosomes and is described in remark 400.
Overview
We describe two structures of the intact bacterial ribosome from Escherichia coli determined to a resolution of 3.5 angstroms by x-ray crystallography. These structures provide a detailed view of the interface between the small and large ribosomal subunits and the conformation of the peptidyl transferase center in the context of the intact ribosome. Differences between the two ribosomes reveal a high degree of flexibility between the head and the rest of the small subunit. Swiveling of the head of the small subunit observed in the present structures, coupled to the ratchet-like motion of the two subunits observed previously, suggests a mechanism for the final movements of messenger RNA (mRNA) and transfer RNAs (tRNAs) during translocation.
About this Structure
2AVY is a Protein complex structure of sequences from Escherichia coli with as ligand. Full crystallographic information is available from OCA.
Reference
Structures of the bacterial ribosome at 3.5 A resolution., Schuwirth BS, Borovinskaya MA, Hau CW, Zhang W, Vila-Sanjurjo A, Holton JM, Cate JH, Science. 2005 Nov 4;310(5749):827-34. PMID:16272117
Page seeded by OCA on Thu Feb 21 16:31:30 2008
