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1zs0

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{{Seed}}
 
[[Image:1zs0.png|left|200px]]
[[Image:1zs0.png|left|200px]]
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==About this Structure==
==About this Structure==
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1ZS0 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZS0 OCA].
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[[1zs0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZS0 OCA].
==Reference==
==Reference==
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[[Category: Tschesche, H.]]
[[Category: Tschesche, H.]]
[[Category: Tucker, P A.]]
[[Category: Tucker, P A.]]
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[[Category: Hydrolase]]
[[Category: Phosphonic inhibitor]]
[[Category: Phosphonic inhibitor]]
[[Category: Stereoselective inhibition]]
[[Category: Stereoselective inhibition]]
[[Category: Sulphonamide junction]]
[[Category: Sulphonamide junction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 08:08:54 2009''
 

Revision as of 20:23, 14 March 2011

Image:1zs0.png

Template:STRUCTURE 1zs0

Crystal structure of the complex between MMP-8 and a phosphonate inhibitor (S-enantiomer)

Template:ABSTRACT PUBMED 16451058

About this Structure

1zs0 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Pochetti G, Gavuzzo E, Campestre C, Agamennone M, Tortorella P, Consalvi V, Gallina C, Hiller O, Tschesche H, Tucker PA, Mazza F. Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates. J Med Chem. 2006 Feb 9;49(3):923-31. PMID:16451058 doi:10.1021/jm050787+
  • Pavlovsky AG, Williams MG, Ye QZ, Ortwine DF, Purchase CF 2nd, White AD, Dhanaraj V, Roth BD, Johnson LL, Hupe D, Humblet C, Blundell TL. X-ray structure of human stromelysin catalytic domain complexed with nonpeptide inhibitors: implications for inhibitor selectivity. Protein Sci. 1999 Jul;8(7):1455-62. PMID:10422833
  • Gavuzzo E, Pochetti G, Mazza F, Gallina C, Gorini B, D'Alessio S, Pieper M, Tschesche H, Tucker PA. Two crystal structures of human neutrophil collagenase, one complexed with a primed- and the other with an unprimed-side inhibitor: implications for drug design. J Med Chem. 2000 Sep 7;43(18):3377-85. PMID:10978185
  • Grams F, Reinemer P, Powers JC, Kleine T, Pieper M, Tschesche H, Huber R, Bode W. X-ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors. Implications for substrate binding and rational drug design. Eur J Biochem. 1995 Mar 15;228(3):830-41. PMID:7737183

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