This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1tmj
From Proteopedia
| Line 1: | Line 1: | ||
| - | {{Seed}} | ||
[[Image:1tmj.png|left|200px]] | [[Image:1tmj.png|left|200px]] | ||
| Line 20: | Line 19: | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[1tmj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TMJ OCA]. | |
==Reference== | ==Reference== | ||
| Line 28: | Line 27: | ||
[[Category: Blaszczyk, J.]] | [[Category: Blaszczyk, J.]] | ||
[[Category: Ji, X.]] | [[Category: Ji, X.]] | ||
| - | [[Category: 6-hydroxymethyl-7 | + | [[Category: 6-hydroxymethyl-7]] |
[[Category: 6-hydroxymethylpterin]] | [[Category: 6-hydroxymethylpterin]] | ||
| + | [[Category: 8-dihydropterin]] | ||
[[Category: Antimicrobial agent]] | [[Category: Antimicrobial agent]] | ||
[[Category: Drug design]] | [[Category: Drug design]] | ||
| Line 38: | Line 38: | ||
[[Category: Pyrophosphoryl transfer]] | [[Category: Pyrophosphoryl transfer]] | ||
[[Category: Structural mutagenesis]] | [[Category: Structural mutagenesis]] | ||
| + | [[Category: Transferase]] | ||
[[Category: X-ray crystallography]] | [[Category: X-ray crystallography]] | ||
| - | |||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 08:15:11 2009'' | ||
Revision as of 20:36, 14 March 2011
Crystal structure of E.coli apo-HPPK(W89A) at 1.45 Angstrom resolution
Template:ABSTRACT PUBMED 15952765
About this Structure
1tmj is a 1 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
- Li Y, Blaszczyk J, Wu Y, Shi G, Ji X, Yan H. Is the critical role of loop 3 of Escherichia coli 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase in catalysis due to loop-3 residues arginine-84 and tryptophan-89? Site-directed mutagenesis, biochemical, and crystallographic studies. Biochemistry. 2005 Jun 21;44(24):8590-9. PMID:15952765 doi:10.1021/bi0503495
- Xiao B, Shi G, Chen X, Yan H, Ji X. Crystal structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, a potential target for the development of novel antimicrobial agents. Structure. 1999 May;7(5):489-96. PMID:10378268
- Blaszczyk J, Shi G, Yan H, Ji X. Catalytic center assembly of HPPK as revealed by the crystal structure of a ternary complex at 1.25 A resolution. Structure. 2000 Oct 15;8(10):1049-58. PMID:11080626
- Shi G, Blaszczyk J, Ji X, Yan H. Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: synthesis and biochemical and crystallographic studies. J Med Chem. 2001 Apr 26;44(9):1364-71. PMID:11311059
Categories: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase | Escherichia coli | Blaszczyk, J. | Ji, X. | 6-hydroxymethyl-7 | 6-hydroxymethylpterin | 8-dihydropterin | Antimicrobial agent | Drug design | Folate | Hppk | Point mutant | Pyrophosphokinase | Pyrophosphoryl transfer | Structural mutagenesis | Transferase | X-ray crystallography
