2bpa
From Proteopedia
(New page: 200px<br /><applet load="2bpa" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bpa, resolution 3.000Å" /> '''ATOMIC STRUCTURE OF...) |
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| - | [[Image:2bpa.gif|left|200px]]<br /><applet load="2bpa" size=" | + | [[Image:2bpa.gif|left|200px]]<br /><applet load="2bpa" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2bpa, resolution 3.000Å" /> | caption="2bpa, resolution 3.000Å" /> | ||
'''ATOMIC STRUCTURE OF SINGLE-STRANDED DNA BACTERIOPHAGE PHIX174 AND ITS FUNCTIONAL IMPLICATIONS'''<br /> | '''ATOMIC STRUCTURE OF SINGLE-STRANDED DNA BACTERIOPHAGE PHIX174 AND ITS FUNCTIONAL IMPLICATIONS'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The mechanism of DNA ejection, viral assembly and evolution are related to | + | The mechanism of DNA ejection, viral assembly and evolution are related to the structure of bacteriophage phi X174. The F protein forms a T = 1 capsid whose major folding motif is the eight-stranded antiparallel beta barrel found in many other icosahedral viruses. Groups of 5 G proteins form 12 dominating spikes that enclose a hydrophilic channel containing some diffuse electron density. Each G protein is a tight beta barrel with its strands running radially outwards and with a topology similar to that of the F protein. The 12 'pilot' H proteins per virion may be partially located in the putative ion channel. The small, basic J protein is associated with the DNA and is situated in an interior cleft of the F protein. Tentatively, there are three regions of partially ordered DNA structure, |
==About this Structure== | ==About this Structure== | ||
| - | 2BPA is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Enterobacteria_phage_phix174 Enterobacteria phage phix174]. Full crystallographic information is available from [http:// | + | 2BPA is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Enterobacteria_phage_phix174 Enterobacteria phage phix174]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BPA OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Enterobacteria phage phix174]] | [[Category: Enterobacteria phage phix174]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Baker, T | + | [[Category: Baker, T S.]] |
| - | [[Category: Ilag, L | + | [[Category: Ilag, L L.]] |
| - | [[Category: Incardona, N | + | [[Category: Incardona, N L.]] |
[[Category: Krishnaswamy, S.]] | [[Category: Krishnaswamy, S.]] | ||
[[Category: McKenna, R.]] | [[Category: McKenna, R.]] | ||
| - | [[Category: Olson, N | + | [[Category: Olson, N H.]] |
| - | [[Category: Rossmann, M | + | [[Category: Rossmann, M G.]] |
[[Category: Willingmann, P.]] | [[Category: Willingmann, P.]] | ||
[[Category: Xia, D.]] | [[Category: Xia, D.]] | ||
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[[Category: single strand]] | [[Category: single strand]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:40:12 2008'' |
Revision as of 14:40, 21 February 2008
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ATOMIC STRUCTURE OF SINGLE-STRANDED DNA BACTERIOPHAGE PHIX174 AND ITS FUNCTIONAL IMPLICATIONS
Overview
The mechanism of DNA ejection, viral assembly and evolution are related to the structure of bacteriophage phi X174. The F protein forms a T = 1 capsid whose major folding motif is the eight-stranded antiparallel beta barrel found in many other icosahedral viruses. Groups of 5 G proteins form 12 dominating spikes that enclose a hydrophilic channel containing some diffuse electron density. Each G protein is a tight beta barrel with its strands running radially outwards and with a topology similar to that of the F protein. The 12 'pilot' H proteins per virion may be partially located in the putative ion channel. The small, basic J protein is associated with the DNA and is situated in an interior cleft of the F protein. Tentatively, there are three regions of partially ordered DNA structure,
About this Structure
2BPA is a Protein complex structure of sequences from Enterobacteria phage phix174. Full crystallographic information is available from OCA.
Reference
Atomic structure of single-stranded DNA bacteriophage phi X174 and its functional implications., McKenna R, Xia D, Willingmann P, Ilag LL, Krishnaswamy S, Rossmann MG, Olson NH, Baker TS, Incardona NL, Nature. 1992 Jan 9;355(6356):137-43. PMID:1370343
Page seeded by OCA on Thu Feb 21 16:40:12 2008
