1bif
From Proteopedia
(New page: 200px<br /> <applet load="1bif" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bif, resolution 2.0Å" /> '''6-PHOSPHOFRUCTO-2-KI...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1BIF is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]] with MG, PO4, ATG and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BIF OCA]]. | + | 1BIF is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]] with MG, PO4, ATG and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Sites: S1, S2 and S3. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BIF OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: transferase (phospho)]] | [[Category: transferase (phospho)]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:17:13 2007'' |
Revision as of 12:12, 30 October 2007
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6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE BIFUNCTIONAL ENZYME COMPLEXED WITH ATP-G-S AND PHOSPHATE
Overview
BACKGROUND. Glucose homeostasis is maintained by the processes of, glycolysis and gluconeogenesis. The importance of these pathways is, demonstrated by the severe and life threatening effects observed in, various forms of diabetes. The bifunctional enzyme, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase catalyzes both the, synthesis and degradation of fructose-2,6-bisphosphate, a potent regulator, of glycolysis. Thus this bifunctional enzyme plays an indirect yet key, role in the regulation of glucose metabolism. RESULTS. We have determined, the 2.0 A crystal structure of the rat testis isozyme of this bifunctional, enzyme. The enzyme is a homodimer of 55 kDa subunits arranged in a, head-to-head fashion, with each monomer consisting of independent kinase, and phosphatase domains. The ... [(full description)]
About this Structure
1BIF is a [Single protein] structure of sequence from [Rattus norvegicus] with MG, PO4, ATG and GOL as [ligands]. Structure known Active Sites: S1, S2 and S3. Full crystallographic information is available from [OCA].
Reference
The crystal structure of the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase reveals distinct domain homologies., Hasemann CA, Istvan ES, Uyeda K, Deisenhofer J, Structure. 1996 Sep 15;4(9):1017-29. PMID:8805587
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