2bzu
From Proteopedia
(New page: 200px<br /><applet load="2bzu" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bzu, resolution 1.50Å" /> '''HUMAN ADENOVIRUS SER...) |
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| - | [[Image:2bzu.gif|left|200px]]<br /><applet load="2bzu" size=" | + | [[Image:2bzu.gif|left|200px]]<br /><applet load="2bzu" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2bzu, resolution 1.50Å" /> | caption="2bzu, resolution 1.50Å" /> | ||
'''HUMAN ADENOVIRUS SEROTYPE 41 FIBER HEAD'''<br /> | '''HUMAN ADENOVIRUS SEROTYPE 41 FIBER HEAD'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Human enteric adenoviruses of species F contain two fibers in the same | + | Human enteric adenoviruses of species F contain two fibers in the same virion, a long fiber which binds to coxsackievirus and adenovirus receptor (CAR) and a short fiber of unknown function. We have determined the high-resolution crystal structure of the short fiber head of human adenovirus serotype 41 (Ad41). The short fiber head has the characteristic fold of other known fiber heads but has three unusual features. First, it has much shorter loops between the beta-strands. Second, one of the usually well-ordered beta-strands on the distal face of the fiber head is highly disordered and this same region is sensitive to digestion with pepsin, an enzyme occurring naturally in the intestinal tract, the physiological environment of Ad41. Third, the AB loop has a deletion giving it a distinct conformation incompatible with CAR binding. |
==About this Structure== | ==About this Structure== | ||
| - | 2BZU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_adenovirus_37 Human adenovirus 37]. Full crystallographic information is available from [http:// | + | 2BZU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_adenovirus_37 Human adenovirus 37]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BZU OCA]. |
==Reference== | ==Reference== | ||
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[[Category: viral protein]] | [[Category: viral protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:43:21 2008'' |
Revision as of 14:43, 21 February 2008
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HUMAN ADENOVIRUS SEROTYPE 41 FIBER HEAD
Overview
Human enteric adenoviruses of species F contain two fibers in the same virion, a long fiber which binds to coxsackievirus and adenovirus receptor (CAR) and a short fiber of unknown function. We have determined the high-resolution crystal structure of the short fiber head of human adenovirus serotype 41 (Ad41). The short fiber head has the characteristic fold of other known fiber heads but has three unusual features. First, it has much shorter loops between the beta-strands. Second, one of the usually well-ordered beta-strands on the distal face of the fiber head is highly disordered and this same region is sensitive to digestion with pepsin, an enzyme occurring naturally in the intestinal tract, the physiological environment of Ad41. Third, the AB loop has a deletion giving it a distinct conformation incompatible with CAR binding.
About this Structure
2BZU is a Single protein structure of sequence from Human adenovirus 37. Full crystallographic information is available from OCA.
Reference
Crystal structure of enteric adenovirus serotype 41 short fiber head., Seiradake E, Cusack S, J Virol. 2005 Nov;79(22):14088-94. PMID:16254343
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