3bif
From Proteopedia
(New page: 200px<br /> <applet load="3bif" size="450" color="white" frame="true" align="right" spinBox="true" caption="3bif, resolution 2.3Å" /> '''6-PHOSPHOFRUCTO-2-KI...) |
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==About this Structure== | ==About this Structure== | ||
| - | 3BIF is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]] with BOG, PO4 and SIN as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.105 2.7.1.105]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=3BIF OCA]]. | + | 3BIF is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]] with BOG, PO4 and SIN as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/6-phosphofructo-2-kinase 6-phosphofructo-2-kinase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.105 2.7.1.105]]. Structure known Active Sites: S1, S2 and S3. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=3BIF OCA]]. |
==Reference== | ==Reference== | ||
A switch in the kinase domain of rat testis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase., Yuen MH, Wang XL, Mizuguchi H, Uyeda K, Hasemann CA, Biochemistry. 1999 Sep 21;38(38):12333-42. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10493801 10493801] | A switch in the kinase domain of rat testis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase., Yuen MH, Wang XL, Mizuguchi H, Uyeda K, Hasemann CA, Biochemistry. 1999 Sep 21;38(38):12333-42. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10493801 10493801] | ||
| + | [[Category: 6-phosphofructo-2-kinase]] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: phosphotransferase]] | [[Category: phosphotransferase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:17:16 2007'' |
Revision as of 12:12, 30 October 2007
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6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE EMPTY 6-PF-2K ACTIVE SITE
Overview
The bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase plays an essential role in the regulation of glucose, metabolism by both producing and degrading Fru-2,6-P(2) via its distinct, catalytic activities. The 6-PF-2-K and Fru-2,6-P(2)ase active sites are, located in separate domains of the enzyme. The kinase domain is, structurally related to the superfamily of mononucleotide binding proteins, that includes adenylate kinase and the G-proteins. We have determined, three new structures of the enzymatic monomer, each with a different, ligand in the ATP binding site of the 6-PF-2-K domain (AMP-PNP, PO(4), and, water). A comparison of these three new structures with the, ATPgammaS-bound 6-PF-2-K domain reveals a rearrangement of a helix that is, dependent on the ligand ... [(full description)]
About this Structure
3BIF is a [Single protein] structure of sequence from [Rattus norvegicus] with BOG, PO4 and SIN as [ligands]. Active as [6-phosphofructo-2-kinase], with EC number [2.7.1.105]. Structure known Active Sites: S1, S2 and S3. Full crystallographic information is available from [OCA].
Reference
A switch in the kinase domain of rat testis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase., Yuen MH, Wang XL, Mizuguchi H, Uyeda K, Hasemann CA, Biochemistry. 1999 Sep 21;38(38):12333-42. PMID:10493801
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