This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2bi7
From Proteopedia
(New page: 200px<br /> <applet load="2bi7" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bi7, resolution 2.00Å" /> '''UDP-GALACTOPYRANOSE...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2BI7 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]] with FAD as [[http://en.wikipedia.org/wiki/ligand ligand]]. This structure superseeds the now removed PDB entry 1USJ. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.9 5.4.99.9]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BI7 OCA]]. | + | 2BI7 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]] with FAD as [[http://en.wikipedia.org/wiki/ligand ligand]]. This structure superseeds the now removed PDB entry 1USJ. Active as [[http://en.wikipedia.org/wiki/UDP-galactopyranose_mutase UDP-galactopyranose mutase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.9 5.4.99.9]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BI7 OCA]]. |
==Reference== | ==Reference== | ||
| Line 14: | Line 14: | ||
[[Category: Klebsiella pneumoniae]] | [[Category: Klebsiella pneumoniae]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| + | [[Category: UDP-galactopyranose mutase]] | ||
[[Category: Beis, K.]] | [[Category: Beis, K.]] | ||
[[Category: Naismith, J.H.]] | [[Category: Naismith, J.H.]] | ||
| Line 23: | Line 24: | ||
[[Category: lipopolysaccharide biosynthesis]] | [[Category: lipopolysaccharide biosynthesis]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:17:27 2007'' |
Revision as of 12:12, 30 October 2007
|
UDP-GALACTOPYRANOSE MUTASE FROM KLEBSIELLA PNEUMONIAE OXIDISED FAD
Overview
Uridine diphosphogalactofuranose (UDP-Galf) is the precursor of the, d-galactofuranose sugar found in bacterial and parasitic cell walls, including those of many pathogens. UDP-Galf is made from, UDP-galactopyranose by the enzyme UDP-galactopyranose mutase. The enzyme, requires the reduced FADH- co-factor for activity. The structure of the, Mycobacterium tuberculosis mutase with FAD has been determined to 2.25 A., The structures of Klebsiella pneumoniae mutase with FAD and with FADH-, bound have been determined to 2.2 A and 2.35 A resolution, respectively., This is the first report of the FADH(-)-containing structure. Two, flavin-dependent mechanisms for the enzyme have been proposed, one, which, involves a covalent adduct being formed at the flavin and the other based, on electron ... [(full description)]
About this Structure
2BI7 is a [Single protein] structure of sequence from [Klebsiella pneumoniae] with FAD as [ligand]. This structure superseeds the now removed PDB entry 1USJ. Active as [UDP-galactopyranose mutase], with EC number [5.4.99.9]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Crystal structures of Mycobacteria tuberculosis and Klebsiella pneumoniae UDP-galactopyranose mutase in the oxidised state and Klebsiella pneumoniae UDP-galactopyranose mutase in the (active) reduced state., Beis K, Srikannathasan V, Liu H, Fullerton SW, Bamford VA, Sanders DA, Whitfield C, McNeil MR, Naismith JH, J Mol Biol. 2005 May 13;348(4):971-82. PMID:15843027
Page seeded by OCA on Tue Oct 30 14:17:27 2007
