2iso
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | {{Seed}} | ||
[[Image:2iso.png|left|200px]] | [[Image:2iso.png|left|200px]] | ||
| - | <!-- | ||
| - | The line below this paragraph, containing "STRUCTURE_2iso", creates the "Structure Box" on the page. | ||
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet) | ||
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| - | or leave the SCENE parameter empty for the default display. | ||
| - | --> | ||
{{STRUCTURE_2iso| PDB=2iso | SCENE= }} | {{STRUCTURE_2iso| PDB=2iso | SCENE= }} | ||
===Ternary complex of DNA Polymerase beta with a dideoxy terminated primer and 2'-deoxyguanosine 5'-beta, gamma-difluoromethylene triphosphate=== | ===Ternary complex of DNA Polymerase beta with a dideoxy terminated primer and 2'-deoxyguanosine 5'-beta, gamma-difluoromethylene triphosphate=== | ||
| - | |||
| - | <!-- | ||
| - | The line below this paragraph, {{ABSTRACT_PUBMED_17209556}}, adds the Publication Abstract to the page | ||
| - | (as it appears on PubMed at http://www.pubmed.gov), where 17209556 is the PubMed ID number. | ||
| - | --> | ||
{{ABSTRACT_PUBMED_17209556}} | {{ABSTRACT_PUBMED_17209556}} | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[2iso]] is a 4 chain structure of [[DNA polymerase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ISO OCA]. | |
| + | |||
| + | ==See Also== | ||
| + | *[[DNA polymerase|DNA polymerase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:017209556</ref><ref group="xtra">PMID:020176482</ref><references group="xtra"/> |
[[Category: DNA-directed DNA polymerase]] | [[Category: DNA-directed DNA polymerase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| Line 35: | Line 26: | ||
[[Category: Nucleotidyl transferase]] | [[Category: Nucleotidyl transferase]] | ||
[[Category: Polymerase]] | [[Category: Polymerase]] | ||
| - | + | [[Category: Transferase-dna complex]] | |
| - | + | ||
Revision as of 17:10, 26 July 2012
Contents |
Ternary complex of DNA Polymerase beta with a dideoxy terminated primer and 2'-deoxyguanosine 5'-beta, gamma-difluoromethylene triphosphate
Template:ABSTRACT PUBMED 17209556
About this Structure
2iso is a 4 chain structure of DNA polymerase with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Sucato CA, Upton TG, Kashemirov BA, Batra VK, Martinek V, Xiang Y, Beard WA, Pedersen LC, Wilson SH, McKenna CE, Florian J, Warshel A, Goodman MF. Modifying the beta,gamma leaving-group bridging oxygen alters nucleotide incorporation efficiency, fidelity, and the catalytic mechanism of DNA polymerase beta. Biochemistry. 2007 Jan 16;46(2):461-71. PMID:17209556 doi:10.1021/bi061517b
- Rajapakse HA, Nantermet PG, Selnick HG, Barrow JC, McGaughey GB, Munshi S, Lindsley SR, Young MB, Ngo PL, Holloway MK, Lai MT, Espeseth AS, Shi XP, Colussi D, Pietrak B, Crouthamel MC, Tugusheva K, Huang Q, Xu M, Simon AJ, Kuo L, Hazuda DJ, Graham S, Vacca JP. SAR of tertiary carbinamine derived BACE1 inhibitors: role of aspartate ligand amine pKa in enzyme inhibition. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1885-9. Epub 2010 Feb 4. PMID:20176482 doi:10.1016/j.bmcl.2010.01.137
