1w7n
From Proteopedia
(New page: 200px<br /> <applet load="1w7n" size="450" color="white" frame="true" align="right" spinBox="true" caption="1w7n, resolution 2.90Å" /> '''CRYSTAL STRUCTURE O...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1W7N is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with PMP as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.4.1.13 4.4.1.13]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W7N OCA]]. | + | 1W7N is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with PMP as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Cysteine-S-conjugate_beta-lyase Cysteine-S-conjugate beta-lyase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.4.1.13 4.4.1.13]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W7N OCA]]. |
==Reference== | ==Reference== | ||
Crystal structure of human kynurenine aminotransferase I., Rossi F, Han Q, Li J, Li J, Rizzi M, J Biol Chem. 2004 Nov 26;279(48):50214-20. Epub 2004 Sep 10. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15364907 15364907] | Crystal structure of human kynurenine aminotransferase I., Rossi F, Han Q, Li J, Li J, Rizzi M, J Biol Chem. 2004 Nov 26;279(48):50214-20. Epub 2004 Sep 10. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15364907 15364907] | ||
| + | [[Category: Cysteine-S-conjugate beta-lyase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:19:13 2007'' |
Revision as of 12:14, 30 October 2007
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CRYSTAL STRUCTURE OF HUMAN KYNURENINE AMINOTRANSFERASE I IN PMP FORM
Overview
The kynurenine pathway has long been regarded as a valuable target for the, treatment of several neurological disorders accompanied by unbalanced, levels of metabolites along the catabolic cascade, kynurenic acid among, them. The irreversible transamination of kynurenine is the sole source of, kynurenic acid, and it is catalyzed by different isoforms of the, 5'-pyridoxal phosphate-dependent kynurenine aminotransferase (KAT). The, KAT-I isozyme has also been reported to possess beta-lyase activity toward, several sulfur- and selenium-conjugated molecules, leading to the proposal, of a role of the enzyme in carcinogenesis associated with environmental, pollutants. We solved the structure of human KAT-I in its 5'-pyridoxal, phosphate and pyridoxamine phosphate forms and in complex with the, ... [(full description)]
About this Structure
1W7N is a [Single protein] structure of sequence from [Homo sapiens] with PMP as [ligand]. Active as [Cysteine-S-conjugate beta-lyase], with EC number [4.4.1.13]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Crystal structure of human kynurenine aminotransferase I., Rossi F, Han Q, Li J, Li J, Rizzi M, J Biol Chem. 2004 Nov 26;279(48):50214-20. Epub 2004 Sep 10. PMID:15364907
Page seeded by OCA on Tue Oct 30 14:19:13 2007
