2eue
From Proteopedia
(New page: 200px<br /><applet load="2eue" size="450" color="white" frame="true" align="right" spinBox="true" caption="2eue, resolution 2.200Å" /> '''Crystal structure o...) |
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| - | [[Image:2eue.gif|left|200px]]<br /><applet load="2eue" size=" | + | [[Image:2eue.gif|left|200px]]<br /><applet load="2eue" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2eue, resolution 2.200Å" /> | caption="2eue, resolution 2.200Å" /> | ||
'''Crystal structure of the protein kinase domain of yeast AMP-activated protein kinase Snf1'''<br /> | '''Crystal structure of the protein kinase domain of yeast AMP-activated protein kinase Snf1'''<br /> | ||
==Overview== | ==Overview== | ||
| - | AMP-activated protein kinase (AMPK) is a master metabolic regulator, and | + | AMP-activated protein kinase (AMPK) is a master metabolic regulator, and is an important target for drug development against diabetes, obesity, and other diseases. AMPK is a hetero-trimeric enzyme, with a catalytic (alpha) subunit, and two regulatory (beta and gamma) subunits. Here we report the crystal structure at 2.2A resolution of the protein kinase domain (KD) of the catalytic subunit of yeast AMPK (commonly known as SNF1). The Snf1-KD structure shares strong similarity to other protein kinases, with a small N-terminal lobe and a large C-terminal lobe. Two negative surface patches in the structure may be important for the recognition of the substrates of this kinase. |
==About this Structure== | ==About this Structure== | ||
| - | 2EUE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http:// | + | 2EUE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EUE OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Amodeo, G | + | [[Category: Amodeo, G A.]] |
[[Category: Bai, Y.]] | [[Category: Bai, Y.]] | ||
| - | [[Category: Rudolph, M | + | [[Category: Rudolph, M J.]] |
[[Category: Tong, L.]] | [[Category: Tong, L.]] | ||
[[Category: kinase domain]] | [[Category: kinase domain]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:14:38 2008'' |
Revision as of 15:14, 21 February 2008
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Crystal structure of the protein kinase domain of yeast AMP-activated protein kinase Snf1
Overview
AMP-activated protein kinase (AMPK) is a master metabolic regulator, and is an important target for drug development against diabetes, obesity, and other diseases. AMPK is a hetero-trimeric enzyme, with a catalytic (alpha) subunit, and two regulatory (beta and gamma) subunits. Here we report the crystal structure at 2.2A resolution of the protein kinase domain (KD) of the catalytic subunit of yeast AMPK (commonly known as SNF1). The Snf1-KD structure shares strong similarity to other protein kinases, with a small N-terminal lobe and a large C-terminal lobe. Two negative surface patches in the structure may be important for the recognition of the substrates of this kinase.
About this Structure
2EUE is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
Crystal structure of the protein kinase domain of yeast AMP-activated protein kinase Snf1., Rudolph MJ, Amodeo GA, Bai Y, Tong L, Biochem Biophys Res Commun. 2005 Dec 2;337(4):1224-8. Epub 2005 Oct 7. PMID:16236260
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