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2bt4

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(New page: 200px<br /> <applet load="2bt4" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bt4, resolution 1.70&Aring;" /> '''TYPE II DEHYDROQUIN...)
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==About this Structure==
==About this Structure==
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2BT4 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]] with PO4, CA2, TRS and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BT4 OCA]].
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2BT4 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]] with PO4, CA2, TRS and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BT4 OCA]].
==Reference==
==Reference==
Rational design of new bifunctional inhibitors of type II dehydroquinase., Toscano MD, Stewart KA, Coggins JR, Lapthorn AJ, Abell C, Org Biomol Chem. 2005 Sep 7;3(17):3102-4. Epub 2005 Aug 1. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16106291 16106291]
Rational design of new bifunctional inhibitors of type II dehydroquinase., Toscano MD, Stewart KA, Coggins JR, Lapthorn AJ, Abell C, Org Biomol Chem. 2005 Sep 7;3(17):3102-4. Epub 2005 Aug 1. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16106291 16106291]
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[[Category: 3-dehydroquinate dehydratase]]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Streptomyces coelicolor]]
[[Category: Streptomyces coelicolor]]
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[[Category: shikimate pathway]]
[[Category: shikimate pathway]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 21:57:02 2007''
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:23:25 2007''

Revision as of 12:18, 30 October 2007

Image:2bt4.gif

2bt4, resolution 1.70Å

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TYPE II DEHYDROQUINASE INHIBITOR COMPLEX

Overview

Selective inhibitors of type II dehydroquinase were rationally designed to, explore a second binding-pocket in the active-site. The molecular, modelling, synthesis, inhibition studies and crystal structure, determination are described.

About this Structure

2BT4 is a [Single protein] structure of sequence from [Streptomyces coelicolor] with PO4, CA2, TRS and GOL as [ligands]. Active as [3-dehydroquinate dehydratase], with EC number [4.2.1.10]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Rational design of new bifunctional inhibitors of type II dehydroquinase., Toscano MD, Stewart KA, Coggins JR, Lapthorn AJ, Abell C, Org Biomol Chem. 2005 Sep 7;3(17):3102-4. Epub 2005 Aug 1. PMID:16106291

Page seeded by OCA on Tue Oct 30 14:23:25 2007

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