1t4v
From Proteopedia
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[[Image:1t4v.png|left|200px]] | [[Image:1t4v.png|left|200px]] | ||
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{{STRUCTURE_1t4v| PDB=1t4v | SCENE= }} | {{STRUCTURE_1t4v| PDB=1t4v | SCENE= }} | ||
===Crystal Structure Analysis of a novel Oxyguanidine bound to Thrombin=== | ===Crystal Structure Analysis of a novel Oxyguanidine bound to Thrombin=== | ||
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{{ABSTRACT_PUBMED_15203151}} | {{ABSTRACT_PUBMED_15203151}} | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: Dysprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]], Hyperprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]], Hypoprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[1t4v]] is a 3 chain structure of [[Hirudin]] and [[Thrombin]] with sequence from [http://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T4V OCA]. | |
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| + | ==See Also== | ||
| + | *[[Hirudin|Hirudin]] | ||
| + | *[[Thrombin|Thrombin]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:015203151</ref><references group="xtra"/> |
[[Category: Hirudo medicinalis]] | [[Category: Hirudo medicinalis]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Thrombin]] | [[Category: Thrombin]] | ||
[[Category: Spurlino, J.]] | [[Category: Spurlino, J.]] | ||
| - | [[Category: Hydrolase]] | + | [[Category: Hydrolase-hydrolase inhibitor complex]] |
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Revision as of 01:59, 27 July 2012
Contents |
Crystal Structure Analysis of a novel Oxyguanidine bound to Thrombin
Template:ABSTRACT PUBMED 15203151
About this Structure
1t4v is a 3 chain structure of Hirudin and Thrombin with sequence from Hirudo medicinalis and Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Lu T, Markotan T, Coppo F, Tomczuk B, Crysler C, Eisennagel S, Spurlino J, Gremminger L, Soll RM, Giardino EC, Bone R. Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis. Bioorg Med Chem Lett. 2004 Jul 16;14(14):3727-31. PMID:15203151 doi:http://dx.doi.org/10.1016/j.bmcl.2004.05.002
