2bt7
From Proteopedia
(New page: 200px<br /> <applet load="2bt7" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bt7, resolution 2.35Å" /> '''STRUCTURE OF THE C-...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2BT7 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Avian_orthoreovirus Avian orthoreovirus]] with SO4 and CD as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BT7 OCA]]. | + | 2BT7 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Avian_orthoreovirus Avian orthoreovirus]] with SO4 and CD as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BT7 OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: viral protein]] | [[Category: viral protein]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:23:27 2007'' |
Revision as of 12:18, 30 October 2007
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STRUCTURE OF THE C-TERMINAL RECEPTOR-BINDING DOMAIN OF AVIAN REOVIRUS FIBRE SIGMAC, CD CRYSTAL FORM
Overview
Avian reovirus fibre, a homo-trimer of the sigmaC protein, is responsible, for primary host cell attachment. The protein expressed in bacteria forms, elongated fibres comprised of a carboxy-terminal globular head domain and, a slender shaft, and partial proteolysis yielded a carboxy-terminal, protease-stable domain that was amenable to crystallisation. Here, we show, that this fragment retains receptor-binding capability and report its, structure, solved using two-wavelength anomalous diffraction and refined, using data collected from three different crystal forms at 2.1 angstroms, 2.35 angstroms and 3.0 angstroms resolution. The carboxy-terminal globular, domain has a beta-barrel fold with the same overall topology as the, mammalian reovirus fibre (sigma1). However, the monomers of the ... [(full description)]
About this Structure
2BT7 is a [Single protein] structure of sequence from [Avian orthoreovirus] with SO4 and CD as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structure of the carboxy-terminal receptor-binding domain of avian reovirus fibre sigmaC., Guardado Calvo P, Fox GC, Hermo Parrado XL, Llamas-Saiz AL, Costas C, Martinez-Costas J, Benavente J, van Raaij MJ, J Mol Biol. 2005 Nov 18;354(1):137-49. Epub 2005 Sep 30. PMID:16236316
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